The National Institute of Mental Health (NIMH) awarded a 5-year, $833,123 Project Grant (CFDA 93.242 Mental Health Research Grants) to Cedars-Sinai Medical Center to investigate the impact of SARS-CoV-2 infection and social determinants of health on inflammation-associated depression risk. The project will leverage expertise from the EMBARC research study to comprehensively study upstream eicosanoid pathways and their relationship to depression following SARS-CoV-2 infection and reinfection. The research aims to provide a detailed understanding of how eicosanoid profiles are altered by SARS-CoV-2 and social determinants of health, and how these changes contribute to the development of neuroinflammatory conditions like depression. This work will lay the groundwork for follow-up studies evaluating anti-inflammatory therapies for modulating eicosanoid variation and improving mental health outcomes.
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