The National Institute of Mental Health (NIMH) awarded Karolinska Institutet in Sweden a 5-year, $1,532,675 Project Grant (CFDA 93.242 Mental Health Research Grants) to conduct the Eating Disorders Genetics Initiative 2 (EDGI2) study. The project aims to identify genetic and environmental risk factors for eating disorders by phenotyping and bio-sampling 20,000 new participants with anorexia nervosa, bulimia nervosa, binge-eating disorder, and avoidant/restrictive food intake disorder. The...
The National Institute of Mental Health (NIMH) awarded a $512,536 Project Grant (CFDA 93.242 Mental Health Research Grants) to the Council of the Queensland Institute of Medical Research, doing business as QIMR Berghofer Medical Research Institute. This funding will support the Eating Disorders Genetics Initiative 2 (EDGI2), a collaborative research effort to advance genomic discovery across major eating disorder types, including anorexia nervosa, bulimia nervosa, binge-eating disorder, and...
This Project Grant award, totaling $1,607,597, was provided by the National Institute of Mental Health (NIMH) under its Mental Health Research Grants program (CFDA 93.242). The funding will support research to elucidate the developmental course and shared versus unique genetic and environmental risk factors underlying eating disorders (ED) and non-eating disorders internalizing-spectrum disorders (NONED-INT), such as major depressive disorder and anxiety disorders.
The research team, led by...
This Cooperative Agreement award, totaling $2,388,169.00, was granted by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award will fund "The ENIGMA - Eating Disorders Initiative: A Global Neuroimaging Study of Anorexia and Factors Affecting Clinical Outcomes." This initiative aims to identify multimodal brain signatures of anorexia nervosa, disentangle the effects of undernutrition on the brain, and longitudinally...
This federal Project Grant award of $248,075.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program supports research to identify genetic, neuroimaging, and behavioral predictors of eating disorders (EDs) in adolescence. The project, titled "Towards an Etiological Model of Adolescent Eating Disorders through Neuroimaging, Genetics, and Behavior", will leverage data from the Adolescent Brain Cognitive Development (ABCD)...
The National Institute of Mental Health (NIMH) awarded a $249,521 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Kansas Center for Research Inc. for the "Building Healthy Eating and Self-Esteem Together for University Students (BEST-U): A Pilot Randomized Controlled Trial of an mHealth Intervention for Binge-Spectrum Disorders" project. This 3-year grant, starting on January 1, 2025, aims to conduct an effectiveness trial of the BEST-U mobile...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $941,616 to North Dakota State University to study the relationship between food cue exposure, food craving, and binge eating behaviors. The researchers will use ecological momentary assessment (EMA) and electroencephalography (EEG) to examine how attention and memory processes influence these factors, with the goal of identifying...
The National Institute of Mental Health (NIMH) awarded a $450,488 project grant under the Mental Health Research Grants program (CFDA 93.242) to the University of Wisconsin - Madison to characterize the acute biobehavioral response to exercise among individuals with restrictive eating disorders (ED). The 2-year project aims to 1) evaluate variability in reward and threat response to exercise, 2) develop tasks to assess exercise-related reward and threat processes, and 3) test hypotheses that...
The National Institute of Mental Health (NIMH) awarded a Project Grant (CFDA 93.242 Mental Health Research Grants) to the University of California, San Diego (UCSD) totaling $874,625 to investigate avoidance learning processes in individuals with anorexia nervosa (AN) and bulimia nervosa (BN). The study aims to differentiate active versus passive avoidance learning strategies and evaluate their association with eating disorder symptoms and neural function. The project will compare avoidance...
The National Institute of Mental Health (NIMH) awarded a $669,049 Project Grant (CFDA 93.242 - Mental Health Research Grants) to North Dakota State University to investigate 24-hour patterns of sleep and negative affect among individuals with recurrent binge eating behavior. The 5-year project aims to: 1) identify 24-hour sleep patterns that signal individual vulnerability for binge eating, and 2) disentangle the bidirectional relationship between sleep and binge eating at a daily level,...
The National Institute of Mental Health (NIMH) awarded a $4,976,892 Project Grant (CFDA 93.242 Mental Health Research Grants) to the University of North Carolina at Chapel Hill (UNC-CH) for the Eating Disorders Genetics Initiative 2 (EDGI2). The project aims to advance genomic discovery across major eating disorders, including anorexia nervosa, bulimia nervosa, binge-eating disorder, and avoidant/restrictive food intake disorder. Key services under the award include:
Phenotyping and bio-sampling 20,000 new participants with eating disorders and controls, with emphasis on underrepresented groups and individuals with severe/enduring anorexia nervosa
Statistical genetic analyses to explicate heterogeneity and biology of eating disorders, including genome-wide association studies and identification of clinically meaningful patient subsets
Evaluation of genetic and environmental risk/resilience factors to inform risk prediction for eating disorders
Identification of brain cell types and anatomical regions implicated by genomic studies, and modeling of genetically regulated gene expression
The project will also involve sub-awards to Comenzar De Nuevo AC in Mexico and Yale University to support participant recruitment/outreach and statistical analysis coordination, respectively.