This $2,576,654 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support the development of a cloud-based software platform and advanced computational pipelines to harmonize and integrate spatial transcriptomics data for the construction of a spatially resolved brain atlas. Key objectives of the 3-year project include: 1) Creating a cloud-based platform to standardize the analysis and visualization of...
The National Institute of Mental Health (NIMH) awarded a $2,515,724 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Regents of the University of Michigan to further develop NTracer2, a cloud-based platform for brain image visualization and neuron tracing. The project aims to establish NTracer2's SISF data framework as a scalable image data standard, continue developing the NTracer2 content delivery network and application server, and deploy the full-stack...
This $299,896 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports the development of a novel modular bioluminescence imaging (BLI) platform called InVivoScan by In Vivo Analytics, Inc. The key products being developed include: A multi-aperture (MA) imaging method featuring a concentric mirror system and stray-light collimator to significantly boost BLI sensitivity and enable multi-view imaging and 3D...
The National Institute of Mental Health (NIMH) awarded a $505,311 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Intelligent Imaging Innovations, Inc. (3i), a for-profit manufacturer of advanced microscopy equipment and software based in Denver, Colorado. The two-year grant, awarded on January 1, 2025, seeks to establish the feasibility of combining recent advances in optical techniques to produce a commercial instrument that enables large-scale, all-optical...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $457,026 to Magnify Biosciences Inc. from August 1, 2024 to July 31, 2026. The goal of this project is to develop a prototype of the "Multiplex Magnify" sample preparation kits as a universal tool for synapse typing and advanced 3D brain imaging in neuroscience research. The key products and services to be delivered include:...
This $401,155 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) will fund the development of a comprehensive software package for accurate and consistent processing and analysis of lifespan brain MRI data. The key products to be delivered include: 1) An anatomy-guided atlas learning neural network to construct lifespan brain...
The National Institute of Mental Health (NIMH) awarded a $600,000 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The University of Texas Southwestern Medical Center in Dallas, TX. The grant will fund the purchase of a Tissuevision Tissuecyte 1600FC Serial Two-Photon Tomography (STPT) microscope to enable high-throughput, high-resolution automated imaging of whole, uncleared rodent brains or spinal cord segments. This advanced imaging system will complement and...
This five-year, $3.74 million project grant from the National Science Foundation's Social, Behavioral, and Economic Sciences program will fund the development of a next generation 9.4 Tesla magnetic resonance imaging system for translational neuroscience research. Awarded on September 1, 2021 to the Research Foundation for Mental Hygiene, Inc., which will perform the work through its Nathan S. Kline Institute division, the grant will support the construction and optimization of an advanced MRI...
The National Institute of Mental Health (NIMH) awarded a Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Weill Medical College of Cornell University for $582,953. The project, titled "The KrackenCoder: A Multi-Modal Connectome Fusion Tool for Brain-Behavior Mapping," aims to create and validate computational tools that integrate and estimate multi-modal brain connectivity data across many individuals, with and without diagnoses, in a behaviorally relevant...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,415,243 to The Broad Institute, Inc. to develop a scalable, cloud-based framework for multi-modal mapping across single neuron omics, morphology, and electrophysiology. The framework aims to enable integrative, data-driven characterization of brain cell types, leveraging federated Brain Initiative resources and community engagement....