Project Grant R01HL181498
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $2,559,308 to examine the impact of severe pre-eclampsia on heart function in diverse racial groups of women. The project will evaluate heart function at delivery and at 6- and 12-months postpartum, as well as characterize the cardiomyopathic genetic profile of the participants. A sub-award of undisclosed amount has been issued to...
- This Cooperative Agreement award, totaling $740,915, was granted by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The overall goal of the award is to elucidate novel mechanisms linking placental ischemia and maternal systemic, cerebral, and renal dysfunction in preeclampsia, and to identify potential therapeutic targets. The University of Mississippi Medical Center, the award recipient, has developed and...
- This federal Project Grant award of $806,978.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Yale University aims to gain insights into maternal endothelial dysfunction and develop novel therapeutic strategies with a focus on plasminogen activator inhibitor 1 (PAI1) as a drug target for preeclampsia. The research seeks to understand how PAI1 contributes to the pathophysiology of preeclampsia, a leading cause of maternal and neonatal...
- The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $720,399 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Colorado-Denver. The 5-year project, running from Sep 1, 2025 to May 31, 2030, will investigate the associations between maternal microbiomes, metabolomes, and cardiovascular health outcomes in a racially and ethnically diverse pregnancy cohort. Key objectives are to characterize...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will fund research to understand disparities in the incidence, outcomes, and post-partum care of hypertensive disorders of pregnancy (HDP). The $502,069 award to Mayo Clinic, a non-profit academic medical center, will quantify the moderating effect of socioeconomic status (SES) on the relationship between urban/rural status and HDP. The research...
- This federal Project Grant award for $696,470, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate the relationship between prenatal maternal sleep and cardiovascular disease risk in offspring. The University of Denver is the primary awardee, and they have sub-awards with Northwestern University and the University of Colorado, Anschutz Medical Center. The key objectives are to: 1) examine how prenatal maternal sleep...
- This federal Project Grant award of $727,080 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the neurogenic mechanisms underlying psychosocial stress-induced cardiovascular disease and postpartum depression. The primary research objective is to delineate how stress-evoked mitochondrial dysfunction in the medial prefrontal cortex contributes to postpartum cardiovascular and behavioral changes. The 4-year project,...
- This Project Grant award of $148,880 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to investigate the long-term effects of preeclampsia (PE) on offspring. The research aims to isolate B cells from the placentas of PE patients and transfer them into pregnant rats to examine the impact on blood pressure, immune cells, cerebrovascular function, and cognitive...
- The National Heart, Lung, and Blood Institute awarded a $156,486 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Denver. The 5-year grant, running from July 2, 2025 to January 5, 2027, will support research examining the association between discrimination reported during pregnancy and cardiovascular disease risk in mothers 3-4 years postpartum. The study will use a prospective longitudinal design with a population of at least 200...
- This Project Grant award of $751,124 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Kaiser Foundation Hospitals supports research focused on the prevention of hypertensive disorders of pregnancy (HDP), which affect 10-15% of pregnancies and are risk factors for future cardiovascular disease in women. The key objectives are to explore the timing and intensity of physical activity, as well as the optimal 24-hour activity composition including...
This federal Project Grant award of $524,179 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research at the University of Utah to integrate multi-omics data to understand the heterogeneity of preeclampsia and long-term postpartum hypertension. The 5-year project aims to leverage whole genome sequencing data and extensive phenotyping from the NuMoM2b-HHS cohort to identify risk variants, gene targets, and pathways associated with preeclampsia and its long-term cardiovascular effects. This research seeks to advance scientific understanding of the underlying genetic and environmental contributors to preeclampsia, a leading cause of maternal and perinatal mortality, and the significant lifelong cardiovascular risks it poses for survivors.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $524.2k | 9/5/25 |