Project Grant R01HL178888
- This Project Grant award of $570,814 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by President and Fellows of Harvard College (Harvard Medical School) to investigate the spatial reach and dynamics of T-cell derived cytokines and their impact on cellular variability within tissues. The key products or services to be delivered include: Characterizing the spatial extent of T-cell derived cytokines such as interleukin-2 and...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $733,785.00 to President and Fellows of Harvard College, Harvard T.H. Chan School of Public Health, to conduct research on identifying and validating biomarkers of plant-rich diets and their associations with cardiovascular disease risk. The key products and services to be delivered under this grant include: 1) Assessing the dose- and time-dependent...
- The federal Project Grant award of $117,525.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is funding research at Boston Children's Hospital to investigate cellular adaptation to perturbations in one-carbon metabolism. The research aims to characterize the role of the UFMylation pathway in maintaining cellular fitness during folate depletion, and explore signaling cascades that promote cellular fitness in response to one-carbon metabolism...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Federal Grant Program CFDA 93.837 - Cardiovascular Diseases Research, will support research to define cellular pathways that regulate lipid flux and elucidate their impact on cardiovascular disease. The $773,259 award, with a project period from December 2024 to November 2028, will enable the University of California, Los Angeles (UCLA) to: 1) Identify novel cholesterol-responsive proteins in the...
- This Project Grant award, valued at $167,400.00 and awarded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), will support research by Brigham & Women's Hospital Inc. to investigate how the immune mediator CD70 regulates endothelial metabolism and function, with the goal of identifying novel therapeutic targets for atherosclerotic cardiovascular disease. The 5-year project will comprehensively examine the role of CD70 in impairing endothelial...
- The federal Project Grant award of $108,978.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the mechanisms underlying the age-related decline in the regenerative capacity of alveolar type 2 (AT2) cells in the lung. The principal investigator and research team at the Harvard T.H. Chan School of Public Health will conduct studies to determine whether elevated interferon gamma (IFNG) levels and changes in resident...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to Baylor College of Medicine provides $128,341 to investigate the role of endothelial cell nucleotide synthesis in atherosclerosis. The research aims to examine how disturbed blood flow induces endothelial DNA damage and the subsequent impact on the endothelial barrier, ultimately contributing to atherosclerotic lesion formation. Key objectives include elucidating...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is funding research to discover novel biomarkers and biological mechanisms underlying early-stage heart failure (HF). The $147,486 award to Duke University will support the development of an automated computational phenotype to identify early-stage HF, which will then be applied to large population cohorts. The research aims to leverage multi-omics data integration and...
- This $548,816 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Illinois to investigate the role of the SEC16B protein in regulating lipid metabolism and transport in the liver. The project aims to define how SEC16B mediates the formation of lipid droplets and very low-density lipoprotein (VLDL) secretion, which are key processes involved in cholesterol and triglyceride homeostasis. This...
- This federal Project Grant award of $1,119,410.00 was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports a multi-disciplinary research initiative to investigate longitudinal changes in DNA methylation (LC-DNAM) and its relationship to cardiovascular disease (CVD) risk factors and outcomes across four large population-based cohort studies - ARIC, CARDIA, FHS, and MESA. The research aims to: 1)...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $692,742 to support research on the role of a novel hormone complex called FABKIN in regulating dyslipidemia and inflammation that contribute to atherosclerosis. The award was made to the President and Fellows of Harvard College, specifically the Harvard T.H. Chan School of Public Health, and runs from September 2025 to May 2029. The research aims to elucidate how FABKIN, which includes fatty acid-binding protein 4 (FABP4), adenosine kinase, and nucleoside diphosphate kinase, regulates lipid metabolism and inflammation through purinergic signaling pathways to promote atherosclerosis development. This project seeks to provide new insights into FABKIN's physiological roles and assess its potential as a therapeutic target for atherosclerosis treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $692.7k | 9/4/25 |