Project Grant R01HL178419

Award Date 8/1/25
Completion Date 5/31/30
Dollars Obligated $507K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Winston-Salem, NC 27157, USA
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  1. Characterize heart cell-specific mitochondrial calcium signaling and functions in HFPEF mouse models, 2) Evaluate the effects of manipulating mitochondrial calcium flux on HFPEF pathogenesis, and 3) Study the molecular mechanisms of mitochondrial dysfunction in HFPEF. This 5-year research project aims to provide insights into cell-specific mechanisms contributing to mitochondrial dysfunction and identify new therapeutic targets for this prevalent but poorly understood form of heart failure.

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