Project Grant R01HL178026
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $742,323 to Vanderbilt University to develop a new bioprosthetic aortic valve made from the pulmonary visceral pleura (PVP) tissue. The research aims to demonstrate the PVP valve's superior mechanical durability, calcification resistance, and hemodynamic performance compared to current bioprosthetic valves, in order to improve the long-term durability of...
- This $298,368 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of a novel device for treating mitral valve regurgitation. The project aims to optimize the device design and procedure through bench testing, followed by acute in vivo studies to demonstrate the feasibility of the approach. The funding recipient, Link Medical LLC, has invented a catheter-based technology intended to restore proper mitral...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will provide $3,008,247 to the University of California, San Diego (UC San Diego) to conduct research on the cell-type specific mechanisms underlying mitral valve prolapse (MVP), a common valvular heart disease. The award will support a multi-disciplinary research effort utilizing single-cell and single-nucleus RNA sequencing and ATAC-sequencing technologies to identify...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $744,145 to Vanderbilt University to develop a new class of antiarrhythmic agents that normalize dysfunctional RYR2 calcium release channels. The overarching goal is to select antiarrhythmic clinical candidates based on ent-verticilide, a potent RYR2 inhibitor. The 4-year project focuses on using cryo-EM and photocrosslinking to elucidate the mechanism of action,...
- This Project Grant award from the National Heart, Lung, and Blood Institute, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $131,571 to Vanderbilt University Medical Center to research methods for improving the trafficking of the KV11.1 potassium channel protein to treat Long QT Syndrome. The project aims to 1) test the drug candidate evacetrapib for its ability to enhance trafficking of KV11.1 variants, and 2) identify protein interactions that could...
- This $834,249 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a comparative study of clinical outcomes, patient experiences, and mechanistic insights between transcatheter and surgical treatment of degenerative mitral regurgitation (DMR). The study aims to provide long-term data on clinical effectiveness, safety, and patient-reported outcomes to inform treatment selection and guide patient care. It will also utilize...
- This Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), will enable Dr. Michael Brener, an interventional cardiologist, to become an independent investigator in the field of valvular heart disease (VHD). The $172,800 award, with a completion date of June 30, 2030, will support Dr. Brener's research using invasive hemodynamics and pressure-volume analysis to better diagnose and...
- This federal Project Grant award of $430,606 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to create a new Pediatric Cardiorespiratory Research Training Program at Vanderbilt University Medical Center (VUMC). The goal is to provide 2-3 years of highly rigorous research training for pediatrics fellows and PhD scientists to facilitate their transition to tenure-track faculty positions as clinician-scientists. The program will support up to 2...
- This federal Project Grant award of $429,000.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will fund a study to investigate the impact of selective vagal neuromodulation on heart failure indices. The 2-year project, with a start date of September 1, 2025, will be conducted by the University of Colorado-Denver. The research aims to better understand the neural interface by studying the effects of selective activation of cholinergic (efferent)...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Vanderbilt University Medical Center (VUMC) provides $173,352 to conduct research on the molecular characterization of frailty and functional limitations in heart failure with preserved ejection fraction (HFpEF). The key objectives are to measure associations between the human proteome and measures of multi-organ function in HFpEF, and to identify and prioritize...
This federal Project Grant award, valued at $759,030.00 and awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of the serotonin 2B receptor (5-HT2B) in degenerative mitral regurgitation and associated left ventricular remodeling. The research, to be conducted by Vanderbilt University from September 1, 2025 to May 31, 2029, aims to decouple the effects of 5-HT2B signaling on mitral valve and left ventricular fibrotic remodeling, with the goal of developing a targeted pharmacological therapy as an alternative to surgical intervention for mitral regurgitation patients. The project will leverage Vanderbilt's expertise in cardiovascular biology and access to selective 5-HT2B receptor modulators to elucidate the causal mechanisms linking mitral valve disease and left ventricular dysfunction.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $759.0k | 8/28/25 |