Project Grant R01HL175992
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to elucidate the complex relationship between obstructive sleep apnea (OSA) and cardiovascular disease (CVD). The $1,296,660 award supports a 24-month research project that will employ a "bed to bench" approach integrating clinical, computational, and in vitro techniques. Key objectives include developing and validating a mathematical model to quantify...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $818,279 to Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, to conduct research on improving the subtyping and characterization of obstructive sleep apnea (OSA). The project will leverage data from existing research cohorts and a clinical biobank to quantify the reproducibility of OSA severity markers and derive physiologically...
- This federal Project Grant award of $843,607, provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research at the Icahn School of Medicine at Mount Sinai to investigate the link between ischemic cardiac injury and its impact on sleep regulation through an immune-mediated heart-brain axis. The research aims to document the neuroimmune pathways that regulate sleep after myocardial infarction (MI) and the consequential brain-heart outputs...
- The National Heart, Lung, and Blood Institute (NHLBI), under CFDA program 93.837 "Cardiovascular Diseases Research", awarded a $1,270,508 Project Grant to the Northern California Institute for Research and Education, Inc. (NCIRE) on September 20, 2025. The grant funds a project titled "Improving Identification of Obstructive Sleep Apnea in Women" that aims to: 1) Identify health factors associated with obstructive sleep apnea in women using electronic health records and...
- This $782,473 federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to improve understanding of the pathogenesis of sleep apnea using novel imaging techniques during sleep. The project aims to characterize the site and pattern of airway collapse as well as how upper airway anatomy mediates this collapse, which could provide new insights to guide optimal therapies, particularly for patients who cannot tolerate...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $526,890 Project Grant to Mayo Clinic to address differential performance by socioeconomic status in artificial intelligence (AI) models for childhood asthma care. The funding, provided through the Cardiovascular Diseases Research federal grant program (CFDA 93.837), aims to develop a framework and tool for measuring differential AI performance, explore the role of electronic health record (EHR) quality on disparities, and create...
- This federal Project Grant award, valued at $678,710 and awarded on June 15, 2025, was provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports the development and validation of a novel multi-sensor machine learning approach to precision sleep tracking for nightshift workers. The project aims to leverage wearable devices, environmental sensors, and machine learning algorithms to accurately detect sleep patterns...
- This federal Project Grant award of $761,028 from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 Cardiovascular Diseases Research will support a multi-site prospective study on hypoxemia during sleep in adults with sickle cell anemia (SCA). The study aims to examine the prevalence, clinical impact, and response to treatment of sleep-related hypoxemia in this patient population across four institutions, including both urban and rural sites. Key activities will involve...
- This $254,250 project grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to advance understanding of the relationship between neighborhood factors and sleep health disparities among first and second grade students, primarily Black children, living in urban New York City neighborhoods. The study will merge a comprehensive public dataset on neighborhood characteristics (Child Opportunity Index 3.0) with a longitudinal dataset from a...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $248,088 to the University of California, San Diego (UCSD) to conduct a mechanistic study on cardiovascular outcomes in patients with comorbid obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD), referred to as overlap syndrome (OVS). The central hypothesis is that poor cardiovascular outcomes in OVS, compared to COPD or OSA alone,...
The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $816,472 project grant to the Icahn School of Medicine at Mount Sinai (ISMMS). The grant, awarded on August 1, 2025 and set to conclude on May 31, 2029, aims to enhance cardiovascular risk prediction and treatment response in obstructive sleep apnea (OSA) patients using advanced AI-based transformer models and multi-modal sleep data. The project will leverage existing epidemiological datasets and clinical trial data to fine-tune a sleep-specific transformer model and improve the ability to predict cardiovascular disease risk and treatment outcomes for OSA patients. This research seeks to address limitations in the current diagnostic marker, the apnea-hypopnea index (AHI), which does not adequately predict individual cardiovascular disease risk or treatment response.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $816.5k | 7/31/25 |