Project Grant R01HL175661

Award Date 7/15/24
Completion Date 6/30/28
Dollars Obligated $545K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Birmingham, AL 35294, USA
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This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $544,610 to the University of Alabama at Birmingham (UAB) to conduct research on the role of fibroblast-macrophage interactions in asbestos-induced toxicity. The research aims to:

  1. Determine which macrophage cell subsets exhibit hedgehog (HH) signaling when co-cultured with human lung fibroblasts, and assess mitochondrial bioenergetics in lung macrophages from subjects with asbestos-induced toxicity.

  2. Identify the specific fibroblast cell type responsible for sonic hedgehog (SHH) production and elucidate the mechanisms by which HH signaling in macrophages mediates metabolic reprogramming towards fatty acid oxidation (FAO).

  3. Evaluate whether constitutive activation of HH signaling in macrophages drives progression of established asbestos-induced toxicity, and if disrupting fibroblast-macrophage communication can abrogate this progression.

The award period runs from July 2024 to June 2028 and leverages innovative techniques, transgenic mouse models, and human tissue samples to advance understanding of fibroblast-macrophage interactions in asbestos-related lung disease.

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