This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $701,440 to Yale University to conduct research on the function of RUVBL1-RUVBL2 proteins in the assembly of dynein arms required for motile cilia in epithelial cells. The research aims to elucidate the mechanism of RUVBL1-RUVBL2 complex formation and systematically define its components and relationships with dynein arm assembly factors associated with primary ciliary dyskinesia, a genetic disease causing cilia motility defects. The award period runs from September 1, 2024 to August 31, 2028. Successful completion of this project is expected to provide a molecular framework for dynein arm assembly and the etiology of primary ciliary dyskinesia, as well as lay the groundwork for future investigations into the regulation and potential interventions for cilia motility under various physiological and disease conditions.
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