Project Grant R01HL173930

Award Date 9/5/24
Completion Date 7/31/28
Dollars Obligated $1.9M
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Boston, MA 02114, USA
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This $2,960,139 Project Grant, awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) on September 5, 2024, supports a comprehensive research project focused on assessing sudden cardiac death (SCD) risk and providing mechanistic insights in patients with arrhythmic mitral valve prolapse (MVP). The project aims to: 1) Perform deep phenotyping of MVP patients to understand characteristics and mechanisms associated with ventricular arrhythmias;...
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This Project Grant award, totaling $1,862,169.00 and funded by the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 Cardiovascular Diseases Research, supports a comprehensive research initiative to investigate the mechanism of myocardial fibrosis induced by mitral valve prolapse (MVP).

The research project, led by The General Hospital Corporation (doing business as Massachusetts General Hospital), aims to elucidate the link between altered mechanical forces caused by MVP and the development of left ventricular myocardial fibrosis, which is strongly associated with ventricular arrhythmias and sudden cardiac death in these patients. The project involves developing a novel surgical MVP model in sheep, quantifying the progression of fibrosis over time, and exploring the molecular pathways activated by the increased mechanical stress. Additionally, the researchers will investigate how the MVP-induced fibrosis predisposes to ventricular arrhythmias. The study involves collaborations with sub-awardees at the Medical University of South Carolina and the University of Arkansas for Medical Sciences, who will contribute expertise in myocardial tissue analysis and cardiovascular biomechanics, respectively.

The award commenced on Sep 5, 2024 and is scheduled for completion on Jul 31, 2028. The research findings are expected to identify novel therapeutic targets to reduce fibrosis and arrhythmias, ultimately preventing sudden cardiac death in patients with MVP.

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