Project Grant R01HL173766

Award Date 8/10/24
Completion Date 5/31/28
Dollars Obligated $693K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Nashville, TN 37203, USA
Similar Awards
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $742,323 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to Vanderbilt University to develop and evaluate a novel bioprosthetic aortic valve based on pulmonary visceral pleura (PVP) tissue. The research aims to address the issue of structural valve degeneration, a major limitation of current transcatheter aortic valve replacement (TAVR) procedures. The award supports an integrated study across in vitro experiments,...
This $750,345 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of telomerase reverse transcriptase (TERT) in the calcification of aortic valves. The University of Pittsburgh, the prime awardee, will conduct experiments to understand the epigenetic and transcriptional changes driven by TERT during the osteogenic reprogramming of aortic valve interstitial...
This $1,927,989 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to understand the mechanisms and develop therapies for congenital aortic valve disease. The awardee, the Research Institute at Nationwide Children's Hospital, will utilize a new mouse model of congenital aortic valve stenosis to define the underlying molecular pathways, examine disease progression, and test potential...
This $207,015 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to elucidate the role of retinoic acid (RA) signaling in the development of cardiac valves. The research, conducted by Childrens Hospital Medical Center in Cincinnati, Ohio, aims to: 1) test the hypothesis that early RA signaling establishes cardiac progenitors necessary to activate Wnt signaling in the...
This federal Project Grant award of $675,614 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of inflammation and biological sex on aortic valve fibrocalcification. The primary award recipient is the University of Colorado, which will develop in vitro models to study sex-specific differences in aortic valve disease progression. Key aspects include: Examining how macrophage and...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to characterize the role of hemodynamic forces and the transcription factors KLF2 and KLF4 in regulating mature heart valve homeostasis. The $159,362 award to The Trustees of the University of Pennsylvania aims to: 1) define the role of hemodynamic forces in maintaining valve homeostasis, 2) identify specific targets of...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $497,401 to 3DT Holdings, LLC, a minority-owned biomedical engineering company, to develop a low-profile transcatheter aortic valve implant (TAVR) system. The project aims to address limitations of current TAVR devices, such as the use of large delivery systems and concerns over long-term durability, by leveraging innovative...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $181,392 to The Leland Stanford Junior University (Stanford University) to optimize surgical techniques for congenital aortic valve disease. The research aims to leverage computational modeling and simulation to guide the design of two promising procedures: bicuspidization repair and bioprinted valve replacement. The goal is to...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research to elucidate mechanisms underlying thoracic aortopathy, a significant cause of morbidity and mortality. The $705,944 award to Yale University, with a period of performance from July 2024 to June 2028, will fund the use of consistent methods to quantify the transcriptional profile and biomechanical phenotype of the...
This $114,938 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research at Brigham & Women's Hospital to investigate the role of epigenetic regulation in the development of calcific aortic valve disease (CAVD). The key objectives are to: 1) define the histone modification profile associated with CAVD progression and corresponding transcriptional regulation, 2) determine how...

This federal Project Grant award of $693,128 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research at Vanderbilt University Medical Center (VUMC) to investigate the role of Tie2 signaling in the remodeling process of aortic heart valves.

The key objectives of this 4-year research project are to: 1) delineate the unique roles of Tie2 signaling in heart valve remodeling using conditional knockout mouse models, 2) define the specific contributions of the Tie2-PI3K/AKT-FOXO1 signaling pathway during semilunar valve remodeling, and 3) identify additional downstream targets of Tie2 activation that regulate heart valve development. This work aims to advance the understanding of normal cardiac valve formation and provide insights into the mechanisms underlying valve formation disorders. The findings could inform future efforts to develop therapies for congenital heart malformations related to abnormal valve development.

Generated 4/8/25, 4:14 AM