Project Grant R01HL173533

Award Date 9/15/24
Completion Date 6/30/29
Dollars Obligated $2.1M
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
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This Project Grant award for $2,130,422 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to comprehensively evaluate lean muscle mass in patients with pulmonary arterial hypertension (PAH). The key objectives are:

  1. Characterize the endophenotype of PAH patients with low lean mass and identify the metabolomic signature, to provide insight into potential pathways.
  2. Assess the role of epicardial adipose tissue in the pathogenesis of low lean mass.
  3. Evaluate the impact of low lean mass on patient-reported outcomes like quality of life and physical activity.
  4. Identify radiographic muscle features on chest CT scans to enable earlier screening for low lean mass in PAH patients.
  5. Conduct a pilot study to explore the response of adiponectin and muscle oxygenation to a low-resistance exercise intervention in PAH patients.

The award will fund this research at the University of Pennsylvania from September 2024 through June 2029, with the goal of laying the foundation for personalized interventions targeting low lean mass in PAH.

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