This federal Project Grant award, totaling $777,497.00, was made by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The purpose of the grant is to study how the circadian clock regulates the immune response to respiratory viruses and affects asthma resolution in children. The award was made to The Washington University, a prominent private research institution, to conduct basic and translational research investigating the role of alveolar macrophages and airway epithelial cells in the age-related pro-resolution response to viral triggers of asthma. The researchers will employ genetic and environmental manipulations to disrupt circadian clock function in mice and analyze antiviral immunity in airway cells from asthma remission patients. This project aligns with NHLBI's research priorities on the circadian regulation of lung disorders and aims to advance the understanding of how the biological clock mediates the beneficial effects of aging on asthma symptoms.
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