The National Heart, Lung, and Blood Institute (NHLBI) awarded Oregon Health & Science University (OHSU) a $751,980 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate cardiomyocyte growth in a fetal ovine model of reduced left ventricular filling. The research aims to understand how cardiomyocytes (heart muscle cells) grow differently in fetuses with impaired left heart inflow, as seen in Hypoplastic Left Heart Syndrome (HLHS). By studying the physical and hormonal factors that regulate cardiomyocyte growth, maturation, and survival before birth, the project seeks to identify ways to optimize cardiomyocyte number in HLHS infants and strengthen their hearts for life-saving surgery and long-term resilience. The award will fund this research from Jul 1, 2024 to May 31, 2028.
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