The University of California, Davis (UC Davis) has been awarded a five-year, $599,342 Project Grant (R01HL171057) from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports an integrative computational and experimental research project aimed at: 1) identifying key molecular and cellular functional changes in heart failure with preserved ejection fraction (HFpEF) using a preclinical animal model, and 2) investigating the impact of HFpEF heterogeneity on disease mechanisms and potential therapies. The research focuses on improving understanding of the phenotypic diversity and altered excitation-contraction coupling observed in HFpEF, which is a major public health burden currently affecting over 3 million Americans. This project will leverage novel functional and transcriptomic data to develop refined modeling platforms for generating quantitative predictions and translating experimental findings across species. The results are expected to provide new insights into HFpEF mechanisms and help identify targeted therapeutic strategies for different patient subpopulations.
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