This federal Project Grant award of $189,686 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support Purdue University's research to elucidate stem cell dynamics in the gametophytes of the fern Ceratopteris. The 3-year project aims to develop mathematical models of cell behavior, uncover the signaling molecules driving spatiotemporal differences in cell division and growth, and associate vertex models with simplified particle models to discover equations of motion from in vivo nucleus trajectories. Through this interdisciplinary approach combining experiments, predictive modeling, and data-driven methods, the research seeks to shed light on how cell division, growth, and differentiation are controlled to maintain meristems and define gametophyte shape, as well as increase the applicability of data-driven methods to collective cell dynamics more broadly.
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