Project Grant R01GM157598
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
- This federal Project Grant award of $222,708 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the mechanistic basis of individual and clustered enhancers in human cells. The goal is to elucidate the molecular mechanisms underlying long-range enhancer-promoter interactions and the role of enhancer clusters in regulating gene expression, with a focus on the MYC locus. The...
- This federal Project Grant award of $667,480.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The award supports fundamental scientific research and advanced training focused on understanding the regulation of genome expression by chromatin and how mutations in chromatin proteins contribute to oncogenesis. The research aims to provide new insights...
- This Project Grant award of $434,679 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research on nuclear envelope dynamics and meiotic quality control mechanisms in the nematode Caenorhabditis elegans. The principal investigator at Lehigh University aims to elucidate how the nuclear envelope and mechanosensitive ion channels like PIEZO transduce signals during meiosis to promote apoptosis when...
- This federal Project Grant award of $393,093, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "Uncovering Spatio-Temporal, Mechano-Transcriptomic Signatures of Development". The principal investigator is Bianca Dumitrascu. The goal of this 5-year project is to understand the interplay between gene expression, cell morphology, and tissue-level mechanics in...
- The federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 - Biomedical Research and Research Training is supporting a $3,125,817 research project at New York University School of Medicine titled "Decoding Positional Epigenetic Memory." The project aims to decipher how stable positional identity is generated through the regulation of HOX gene expression, which is crucial for proper cell differentiation and disease...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $431,656 Project Grant to the University of Massachusetts to elucidate the function of ribonucleoprotein (RNP) condensates in living cells. The research aims to develop novel methods to accurately identify the RNA-binding proteins that regulate the formation and disassembly of RNP condensates, which play a crucial role in cellular function and disease...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $387,500 Project Grant to The Johns Hopkins University on May 1, 2025. The funding supports a research program that systematically investigates the roles of conserved microRNAs during animal development. The research leverages the experimental system provided by C. elegans, utilizing state-of-the-art molecular biology and genetics approaches. The...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $127,145 to The Trustees of Princeton University to conduct research dedicated to unraveling the regulatory mechanisms governing chromatin organization and gene transcription during neural development in the Drosophila model organism. The primary focus is on understanding how...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to investigate how the nuclear protein lamins regulate genome organization and gene expression during development. The $335,000 award to the Carnegie Institution of Washington will be used to study the mechanisms by which lamins control 3D chromatin interactions and gene regulation in mouse embryonic stem cells and embryonic tissues. The research will build upon recent advances in mapping chromatin-lamina associations and 3D genome organization to discover how lamin mutations lead to changes in global chromatin interactions and gene expression. The project will run from September 9, 2025 to August 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $335.0k | 9/9/25 |