Project Grant R01GM157525
- This $289,856 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate the molecular and structural mechanisms underlying the licensing of DNA replication origins in multicellular eukaryotes. The research will employ biochemical, biophysical, and structural biology approaches to resolve how metazoan MCM helicase loading intermediates mature into active replication...
- The National Institute of General Medical Sciences (NIGMS) awarded a $468,875 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Oklahoma Medical Research Foundation (OMRF) for the project "Regulation of Gene Transcription and DNA Replication by Chromatin Readers from the BET Family." The project aims to elucidate the roles of bromodomain and extra-terminal (BET) proteins in coordinating the regulation of gene transcription and DNA...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $390,000.00 to The Regents of the University of Colorado (University of Colorado-Denver) to conduct research on the molecular mechanisms of DNA replication during mitosis. The research aims to uncover how cells complete replication of the entire genome before cell division, even when replication is not fully finished in the S phase of...
- This federal Project Grant award for $426,250.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the Oklahoma Medical Research Foundation (OMRF). The grant supports two research projects focused on understanding how different chromatin regulator complexes influence facultative heterochromatin balance and organization. The first project examines the opposing roles of three SWTICH/SNAF chromatin...
- This Project Grant award of $254,919.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of California, San Diego (UCSD) to investigate the regulatory mechanisms that ensure accurate transmission of the genome during cell division. Specifically, the research aims to study how post-translational modification enzymes regulate the assembly and function of DNA replication...
- This federal Project Grant award of $427,571.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project titled "Maintenance of Cellular Memory During Replication" at the University of Colorado-Denver. The project aims to uncover the molecular determinants of cellular identity and how chromatin states are regulated across the cell cycle. Key objectives...
- This federal Project Grant award of $1,943,750.00, awarded on August 8, 2025, is provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research and advanced training focused on understanding the molecular mechanisms that regulate the mitotic DNA damage response. The project, led by researchers at The Washington University, aims to 1) reveal how ubiquitinated histone H2A acts...
- This $516,608 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the mechanisms and regulation of DNA recombination in budding and fission yeast. The key research focus areas are: 1) studying DNA end resection, the critical first step in homologous recombination, within heterochromatin regions, 2) investigating how lagging strand synthesis proceeds during...
- This federal Project Grant award for $2,463,036, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the establishment of the Center for Genomic Regulation (CGR) at the Oklahoma Medical Research Foundation (OMRF). The goal of the CGR is to build a focused research community that performs collaborative research and effective training in the area of genomic regulation, which includes studies...
- This $2,285,694 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at Tufts University to study the relationship between DNA replication and tandem repeat instability. The grantee will combine genetic assays and single-cell live microscopy analysis in a model system to understand how repeat length changes during replication. This dual approach will examine how a repeat's length, propensity to form DNA structures, and orientation...
This $787,710 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate the fundamental mechanisms governing the regulation of DNA replication origin firing efficiency. The research, conducted by the Oklahoma Medical Research Foundation (OMRF), aims to determine the mechanisms by which two essential origin firing factors, TICRR/TRESLIN and MTBP, are recruited to replication origins, as well as explore how transcription factors and chromatin modifications influence origin specification and firing throughout the cell cycle. Additional goals include uncovering how TICRR/TRESLIN and MUVB-MYBL2 coordinate mitotic entry with DNA replication completion. The award period is from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $787.7k | 8/28/25 |