This Project Grant award of $460,625 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand the mechanisms by which post-sepsis exercise therapy can regulate CD4 T cell immunity and protect against secondary Pseudomonas aeruginosa infections in sepsis survivors. The 2-year study, which commenced on July 7, 2025, will be conducted by the Feinstein Institutes for Medical...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is for a study titled "Targeting Mitochondrial Permeability Transition to Attenuate Adverse Muscle Impact in Sepsis". The $193,188 award, effective from Sep 1, 2024 to Aug 31, 2026, will investigate the role of mitochondrial permeability transition (MPT) in skeletal muscle dysfunction...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) aims to unravel the relationships between gut and blood microbial signatures and immune responses in sepsis patients. The $403,750 award to Duke University will support a prospective longitudinal study to integrate gut microbial community profiling, metabolomics, measures of intestinal permeability, and blood microbial signatures with immune...
The National Institute of General Medical Sciences (NIGMS) awarded a $350,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Medosome Biotec LLC, a for-profit limited liability company. The grant, awarded on September 12, 2024, will support research and development to evaluate the safety and therapeutic potential of dichloroacetate (DCA) as a treatment for sepsis. Medosome Biotec will collaborate with researchers at the University of Florida, Wake...
This Project Grant award of $455,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to decrease sepsis mortality in the pediatric population. The key products and services to be delivered include: Developing an AI-guided early sepsis identification tool to enable timely diagnosis and treatment. Performing sepsis phenotyping and creating digital twin patient models to predict personalized treatment responses....
This $598,228 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to investigate the role of endoplasmic reticulum autophagy (ER-phagy) in the immune response during sepsis. The research team at the University of Illinois will use state-of-the-art methods to define the mechanisms by which ER-phagy regulates the NLRP3 inflammasome activation and cytokine release in macrophages, ultimately contributing to lung injury during...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $166,204 to Dr. Nicholas P. Semenkovich and the Medical College of Wisconsin to develop and advance cell-free DNA as a novel biomarker with predictive and prognostic roles in sepsis. The primary research goal is to use machine learning methods to identify septic patients at risk of complications, and test these...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $170,900.00 to Rowan University to research methods for optimizing autophagy to counteract aging-induced muscle deterioration (sarcopenia) in mice. The research aims to 1) define the role of the GAPR-1 protein in sarcopenia, and 2) determine the efficacy of combining the autophagy agonist TAT-Beclin1 with endurance exercise to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $190,278 to The Regents of the University of California, San Francisco (UCSF) to investigate the role of transposable elements in septic immune aging. The key objectives of this 5-year project are to: 1) study the dynamics of transposable element de-repression as a function of age and sepsis, 2) employ machine learning to...
The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $174,960 Project Grant to the Regents of the University of Michigan on February 1, 2025. The grant supports Dr. Elizabeth Munroe's research to develop and evaluate a personalized approach to initial fluid resuscitation in patients with hospital-onset sepsis. The key objectives are to: 1) understand the impact of initial fluid volume on outcomes in patients with...