This Project Grant award, funded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program, focuses on understanding the role of the transcription factor Nrf2 in regulating T cell function and the immune response to influenza. The $510,251 award to the partnership between Henry Ford Health and Michigan State University Health Sciences aims to elucidate the mechanism by which the synthetic food additive tert-butylhydroquinone (TBHQ) activates Nrf2, and how this impacts the development of antiviral CD4 and CD8 T cell responses and memory T cell function in the context of influenza infection. The project period runs from July 6, 2024 to April 30, 2029. As a sub-awardee, the partnership also contributes to the broader research portfolio of the Environmental Health program, which supports scientific investigations into the health implications of environmental exposures and the development of strategies for prevention and mitigation.
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