Project Grant R01EB038780
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded the Regents of the University of Minnesota a Project Grant of $531,021 under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award, effective April 10, 2026, with completion targeted for January 31, 2030, supports technology development for whole brain functional and structural connectivity mapping at 10.5 Tesla (10.5T)...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the Regents of the University of Minnesota $492,931 under the Biomedical Research and Research Training program (CFDA 93.859) for research on synthetic protein engineering. The award, effective April 1, 2026, through January 31, 2031, supports the development and refinement of a Multiplexed Assays of Variant Effect (MAVE) pipeline designed to advance understanding of how cellular context...
- Federal Project Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded the Regents of the University of Minnesota a $654,117 Project Grant (CFDA 93.286: Discovery and Applied Research for Technological Innovations to Improve Human Health) effective April 1, 2026, through March 31, 2030. The project addresses the critical challenge of ensuring safe, effective, and trustworthy artificial intelligence (AI) deployment across U.S. healthcare delivery...
- Federal Grant Award Summary The University of Minnesota's Regents received a $188,627 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2030. The award supports the development and refinement of KINATEST-ID, a platform technology designed to measure post-translational modification enzyme activity, specifically kinase activity, both in...
- Federal Project Grant Award Summary The University of Minnesota received a $333,290 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026, through February 28, 2031. The award supports the development of a comprehensive analytical framework for integrating multi-source, multi-way, and multi-cohort high-throughput biomedical data. The research team will create flexible...
- Federal Project Grant Award Summary The University of Minnesota received a $398,144 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026, through January 31, 2031. The award funds research to develop immunocompetent tissue models by combining human pluripotent stem cells (HPSCs) and genetic engineering techniques to create microtissues containing tissue-resident macrophages...
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded the University of Missouri System $418,043 under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) for a two-year project grant running from August 1, 2025, through July 31, 2027. The project deliverables center on the design and development of a self-tunable messenger RNA (mRNA) circuit capable of sustained, precise regulation...
- Federal Project Grant Award Summary The University of Minnesota's Office of Sponsored Projects Administration received a $404,058 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through June 30, 2030. This award supports fundamental biomedical research investigating single-molecule imaging and the mechanisms of crossover regulation on meiotic chromosomes. The...
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded the Regents of the University of Michigan a Project Grant of $2,604,736 (awarded May 16, 2025, through April 30, 2030) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award establishes a National Center for Biomedical Imaging and Bioengineering (NCBIB) at the University of Michigan to develop microsystems-based...
- Federal Project Grant Award Summary The University of Minnesota received a $249,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on methods for radical hydroamination via boryl radical chemistry. The award, effective September 1, 2025, through August 31, 2028, supports fundamental organic and organometallic chemistry research combining experimental and computational...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded $471,967 to the Regents of the University of Minnesota on May 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). This project grant supports the development of dual density-dependent molecular AND gate binders—engineered bispecific targeting ligands designed to selectively bind cells expressing high levels of two distinct antigens simultaneously. The research leverages modular synthetic miniproteins and an integrated experimental/computational approach to advance precision medicine by achieving ultraselectivity in therapeutic delivery, thereby reducing on-target, off-disease toxicity that limits current therapeutic windows. The project will deliver engineered targeting agents that demonstrate selective binding through cooperative avidity mechanisms, with specific application to TROP2/EGFR density-dependent bispecific targeting validated in murine tumor models. The research will produce systematic insights into the molecular design principles governing density-dependent binding and cooperativity in bispecific systems, enabling rational tailoring of engineered avidity for improved cell specificity. The award period extends through February 28, 2030, and represents an investment in hypothesis- and design-driven biomedical technology development aimed at establishing foundational knowledge and practical tools for next-generation therapeutic targeting platforms.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $472.0k | 4/10/26 |