This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $2,278,167 to the University of North Carolina at Chapel Hill to develop ultra-high precision image-guided incisionless transcranial ultrasound surgery. The key objectives are to combine advancements in volumetric super-resolution imaging, targeted contrast agents,...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,360,447.52 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), with a project period from Sep 1, 2024 to Aug 31, 2027. The grant funds the development and evaluation of an inexpensive, lightweight "brain monitor" device using...
This $2,291,527 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will fund research and development of an advanced ultrasound imaging system to improve the monitoring and treatment of renal cell carcinoma (RCC) using histotripsy therapy. The key objectives are to: 1) Integrate an ultrafast, bubble-specific ultrasound...
This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $399,294 to the University of Virginia to develop focused ultrasound-mediated drug delivery approaches to improve treatment of primary and metastatic brain tumors. The key objectives are to: 1) Identify optimal timing windows for vascular normalization to enhance focused ultrasound and microbubble-mediated delivery of small molecule drugs and antibody-based immunotherapies...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will fund the development of breakthrough technology to enable future compact, mid-field (0.7 Tesla) magnetic resonance imaging (MRI) systems. The $499,291 award, effective September 1, 2024 through August 31, 2025, will be used by the Regents of the University of Minnesota,...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 3-year, $3,582,963 Project Grant under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) to Carnegie Mellon University (CMU). The grant supports the development and validation of novel wearable transcranial focused ultrasound (TFUS) neuromodulation transducer array probes compatible with simultaneous electrophysiological recordings in behaving...
This $545,630 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program supports the development of bispecific antibody (BAB) immunocytokine shuttles for non-invasive and long-term delivery of regulatory T cell (Treg)-inducing cytokines, such as interleukin-2 (IL-2), to the central nervous system (CNS). The key objectives are...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $390,616 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to the Regents of the University of Michigan for the development of layer-specific functional magnetic resonance imaging (fMRI) techniques for clinical 3 Tesla scanners. The goal is to improve signal-to-noise ratio and reduce scan time for layer-specific fMRI, which currently...
This $179,130 Project Grant awarded by the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) will support a research project at the University of Maryland, Baltimore to evaluate the use of focused ultrasound combined with antibody immunotherapy for treating glioblastoma, an aggressive type of brain cancer. The key objectives are to: 1) use PET imaging to characterize the delivery and pharmacokinetics of an anti-CD47 antibody immunotherapy when combined with focused ultrasound to...
The University of Michigan was awarded a $184,010 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program. The grant, titled "MICHIGAN TRANSLATIONAL IMAGING PROGRAM (M-TIP)", aims to develop a postdoctoral training program in translational medical imaging. The program will foster collaboration between basic science and...