Project Grant R01EB036841

This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program, provides $150,000 to Oregon State University (OSU) to develop a personalized therapeutic drug monitoring (PTDM) system for tracking anti-seizure medication levels. The key objectives are to: 1) create a personalized drug titration pharmacokinetic model; 2) develop electrochemistry assays for measuring two anti-seizure drugs in saliva; 3) build electronic, electrochemical, and computational components for a field-use PTDM platform; and 4) integrate and validate the complete field-use PTDM system. The project aims to address critical barriers in leveraging variable pharmacokinetics and saliva sample challenges for personalized drug monitoring, with the goal of transforming treatment for chronic conditions. The award period runs from September 2024 through May 2028.