Project Grant R01EB034820
- This Project Grant award of $630,982 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research by the General Hospital Corporation, doing business as Massachusetts General Hospital, to conduct a noninvasive optical assessment of neuroprotection during deep hypothermic circulatory arrest procedures. The research aims to better understand and mitigate neurological...
- This $498,995 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports the development of a highly parallelized interferometric near-infrared spectroscopy (INIRS) platform for the real-time, non-invasive measurement of cerebral blood flow. The research aims to address the limitations of current stroke diagnosis and monitoring techniques...
- This $385,755 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) is supporting the development of a non-invasive, wearable core body thermometer to enable better estimation of internal body temperature, with a focus on monitoring brain temperature during critical medical procedures. The key product being developed under this grant is a novel sensor technology that can accurately measure internal body temperature, including brain...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $541,109 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Washington. The 5-year grant, beginning January 1, 2025, will fund research to quantify myelin loss and recovery in ischemic stroke patients using a novel magnetic resonance imaging (MRI) technique called single-point macromolecular proton fraction (MPF) mapping. The...
- This Project Grant award for $580,614 was issued on September 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research at the University of Alabama at Birmingham (UAB) to investigate and validate a magnetic resonance spectroscopic imaging and thermometry (MRSI-T) technique for in vivo visualization of neuroinflammation in patients with...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $251,313 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Yale University on August 1, 2025. The grant funds research to prospectively identify hypoxic ischemic brain injury (HIBI) using portable magnetic resonance imaging (MRI) in cardiac arrest patients. The research will evaluate the use of low-field portable MRI to detect HIBI, which is a key...
- This Project Grant award of $338,232.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new machine learning method that leverages partially synthetic data for rapid and precise pH mapping in ischemic stroke. The research project seeks to advance an MRI pH imaging technique called Amide Proton Transfer (APT) to better delineate...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $653,192 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The grant supports a 5-year longitudinal study to quantify fibrin deposition in the brain using a novel molecular imaging approach based on 64Cu-FBP8 PET. The research aims to investigate the...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $476,993 to Yale University to develop new methods for measuring white matter hyperintensities (WMH) using low-field portable MRI (PMRI) technology. The project aims to create both a qualitative WMH grading scale and a quantitative machine learning-based WMH volume...
- The National Institute of Neurological Disorders and Stroke (NINDS), through its Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), awarded a $936,787 Project Grant to Magnetic Tides, Inc. to evaluate a novel non-invasive brain stimulation approach called Kilohertz Transcranial Magnetic Perturbation (KTMP) for improving upper limb motor function in chronic stroke patients. The 3-year award period from September 1, 2025 to August 31, 2028 will be used to...
ABSOLUTE BRAIN THERMOGRAPHY USING MULTINUCLEAR MRI - PROJECT SUMMARY STROKE IS THE LEADING CAUSE OF DISABILITY, THE SECOND LEADING CAUSE OF DEMENTIA, AND THE SECOND LEADING CAUSE OF DEATH WORLDWIDE, AFFECTING NEARLY 800,000 PATIENTS PER ANNUM IN THE U.S. ALONE. CEREBROVASCULAR ISCHEMIA IS RAPIDLY POTENTIATED BY RISING BODY TEMPERATURES, OCCURRING EVEN WITH MILD AND SUB-FEBRILE HYPERTHERMIA. THE POTENCY OF HYPERTHERMIC DAMAGE IN ISCHEMIC BRAIN ARISES DUE TO IMPAIRED COOLING IN HYPOPERFUSED BRAIN TISSUES. CONSEQUENTLY, LOCALIZED BRAIN HYPERTHERMIA CAN PRECEDE, AND COMMONLY EXCEEDS, SYSTEMIC TEMPERATURE CHANGES FOLLOWING ISCHEMIC INJURY, AND IS WELL-RECOGNIZED AS ACCELERATING STROKE PROGRESSION AND CONSUMPTION OF AT-RISK TISSUES. DESPITE SEVERE WORSENING OF CLINICAL OUTCOMES AMONG FEBRILE STROKE PATIENTS, THE DEVELOPMENT OF PROGNOSTIC BIOMARKERS AND ROBUST TREATMENT TARGETS IN PERI-ISCHEMIC CEREBRAL HYPERTHERMIA REMAINS UNREALIZED DUE TO LACK OF PRAGMATIC MEANS TO ACQUIRE ACCURATE SPATIALLY-RESOLVED CEREBRAL THERMOGRAPHS. MR THERMOMETRY (MRT) USING THE PROTON RESONANCE FREQUENCY (PRF) CHEMICAL SHIFT WITH 1H-MR SPECTROSCOPY (MRS) HAS BEEN EXPLORED FOR NON-INVASIVE CEREBRAL THERMOGRAPHY. DESPITE PROMISING RESULTS, SEVERAL FUNDAMENTAL LIMITATIONS UNDERMINE ESTIMATION OF ABSOLUTE TEMPERATURE AND THUS IMPEDE DEVELOPMENT OF MEANINGFUL CLINICAL PARADIGMS, INCLUDING: 1) THE LOCAL ENVIRONMENT IN TISSUES CAN SIGNIFICANTLY ALTER PERFORMANCE AND AFFECT TEMPERATURE ESTIMATION; 2) MAGNETIC FIELD FLUCTUATIONS CAUSED BY PHYSIOLOGICAL- AND HARDWARE-RELATED NOISE INTRODUCE LARGE ERRORS IN TEMPERATURE ESTIMATION; AND 3) LOW TEMPERATURE SENSITIVITY AND SIGNAL-TO-NOISE OF SPECTROSCOPIC IMAGING APPROACHES HINDER IN VIVO ACCURACY. THIS APPLICATION ADDRESSES SUCH CHALLENGES TO FULFILL THE ELUSIVE AIM OF ABSOLUTE MR THERMOMETRY USING NOVEL MULTINUCLEAR THERMOMETRY DEVELOPED BY THE INVESTIGATORS. INITIAL RESULTS SUGGEST SIGNIFICANTLY HEIGHTENED IMMUNITY TO B0 DRIFT, SUSCEPTIBILITY, AND PH, AND HIGHER SNR PER-UNIT TIME, RELATIVE TO MRS APPROACHES. THESE DEVELOPMENTS SUPPORT AN UNPRECEDENTED LEVEL OF OVERALL ACCURACY, AND IN THIS APPLICATION WE APPLY THIS APPROACH TOWARDS DEVELOPMENT OF ABSOLUTE 3D WHOLE- BRAIN THERMOMETRY FOR DETECTION AND CHARACTERIZATION OF ISCHEMIC CEREBRAL HYPERTHERMIA.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $387.5k | 4/21/25 | ||
| Not listed | $0 | 10/29/24 | ||
| Not listed | $0 | 10/29/24 | ||
| Not listed | $551.6k | 7/30/24 | ||
| Not listed | $551.6k | 7/30/24 |