Project Grant R01DK142076
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $133,333 Project Grant to Yale University to study the mechanisms underlying the myeloid bias in aged hematopoietic stem and progenitor cells (HSPCs). The research aims to correct this myeloid bias by preventing the turnover of the linker histone H1.0, which could have implications for addressing diverse...
- This federal Project Grant award of $122,454, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research investigating the role of the GIMAP5 gene in maintaining liver homeostasis. The primary recipient, Yale University, is conducting studies to determine how loss of function in the GIMAP5 gene leads to capillarization and dedifferentiation of liver...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $2,999,512 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The University of Texas Southwestern Medical Center, doing business as Southwestern Medical School. This 4-year award, starting on September 1, 2025, will support research to investigate the regulation of mitochondrial health in mammalian livers, with a focus on understanding the...
- This federal Project Grant award of $155,443 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research on the role of blood vessel endothelial cells in intestinal regeneration and inflammatory bowel disease. Led by Dr. Brisa Palikuqi at Yale University, the research utilizes mouse models, immune profiling, single cell RNA sequencing, and spatial transcriptomics...
- This Project Grant award of $806,192 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to delineate how a deficiency in the ATP-binding cassette protein MRP9 causes injury to cholangiocytes, the cells that line the bile ducts, in chronic cholestatic liver diseases. The research is being conducted by the Children's Hospital Medical...
- This $1,558,188 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate how changes in transcription factor and heterochromatin states in embryos and adult livers impact hepatocyte development, homeostasis, and regeneration. The project, led by researchers at the University of Pennsylvania, will utilize advanced...
- The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $222,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Beckman Research Institute of the City of Hope. The grant supports research to understand how conjugated bile acids regulate metabolism after bariatric surgery, with the goal of developing safer and more affordable treatments for obesity and fatty liver disease. Key activities include...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a component of the National Institutes of Health, awarded a $292,116 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Renovate Biosciences Inc. The grant aims to generate human livers from donor patient-specific cells using pigs as a "bio-incubator" for xenotransplantation, with the long-term goal of producing immune-compatible solid organs for...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $640,001 to Yale University to conduct research on the mechanisms and function of the protein Polycystin-1 (PC1) in the context of autosomal dominant polycystic kidney disease (ADPKD). The key objectives are to: 1) determine if a specific 200 amino acid fragment of PC1 can...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $497,370 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the Regents of the University of Michigan. The grant, titled "CD45 MEDIATED REGULATION OF PMN FUNCTION DURING INTESTINAL INFLAMMATION", will fund research to determine the effects of neutrophil-specific loss of the CD45 tyrosine phosphatase on intestinal inflammation and repair processes. The...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $3,233,421 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Yale University. The grant, with a performance period of September 1, 2025 to August 31, 2029, will support research to investigate the role of neutrophils in the pathogenesis of cholangiopathies - chronic liver diseases affecting bile ducts. The research aims to elucidate the pathophysiological consequences of neutrophil infiltration into the portal regions of the liver in certain cholangiopathic disorders, which remains poorly understood. Yale will leverage advanced techniques, including single-cell transcriptomic analysis, to characterize the distinct properties of periductular neutrophils compared to those in the bloodstream, with the goal of gaining new insights into the regulatory functions of neutrophils in cholangiopathies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 8/20/25 |