Project Grant R01DK138871

Award Date 1/20/25
Completion Date 11/30/27
Dollars Obligated $307K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Columbus, OH 43210, USA
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This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $163,421.00 in funding to Pennsylvania State University (Penn State) to conduct research on dietary predictors of new-onset diabetes following acute pancreatitis. The primary objective is to determine the role of various dietary patterns, including healthy plant-based and...
This Project Grant award for $666,890.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund a 24-week parallel-group randomized controlled trial to evaluate the efficacy of the antihyperglycemic medications pioglitazone versus empagliflozin in treating chronic pancreatitis with diabetes mellitus (CP-DM). The trial will be conducted at the...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $808,866 to Progenra Inc. to develop and evaluate novel small molecule activators of the ubiquitin proteasome system (UPS) as potential therapeutic interventions for acute and chronic pancreatitis. The research aims to leverage prior discoveries on the role of mitophagy in pancreatitis...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $125,162 to the University of Florida to measure changes in central carbon and lipid metabolism in the exocrine pancreas of a mouse model of type 1 diabetes. The research will utilize novel pancreas perfusion methods combined with nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry...
The National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases awarded $3.6 million under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Anagram Therapeutics Inc. to develop a novel pancreatic enzyme replacement therapy. Specifically, Anagram will engineer lipase enzymes for improved stability against low pH and proteolytic degradation. This will allow for effective digestion of fats in both the stomach and small...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $620,414 to The Leland Stanford Junior University to elucidate novel mechanisms for acute pancreatitis through calcineurin signaling. The key objectives are to: 1) Define the phosphosignaling networks, including signatures regulated by calcineurin activity in acute pancreatitis, 2)...
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This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to define the molecular determinants of inflammatory memory in the pancreas. The $506,546 award, with a performance period from July 1, 2024 to May 31, 2029, will be performed by the Weill Medical College of Cornell University. The research aims to leverage...
This $199,999 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports the development of innovative artificial intelligence (AI)-based methods to discover potent, orally available small-molecule heparanase inhibitors. Heparanase is an enzyme that plays a key role in the development of diabetic nephropathy, a complication of diabetes...
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The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $306,994 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Ohio State University. This pilot clinical trial project aims to assess the safety, compliance, and efficacy of a novel soy-tomato dietary intervention to reduce inflammation and improve outcomes in individuals with chronic pancreatitis. The key products/services to be delivered include: 1) Conducting a pilot clinical trial to evaluate the tolerability and compliance of the soy-tomato dietary intervention in chronic pancreatitis patients, and 2) Assessing the intervention's ability to reduce systemic inflammation and improve patient-reported outcomes. The Ohio State University will serve as the prime awardee for this 2-year project, with a performance period from January 20, 2025 to November 30, 2027. This award supports critical research to develop a potential nutritional therapy to address the inflammatory and metabolic complications associated with chronic pancreatitis.

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