This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), aims to investigate the molecular mechanisms that establish and maintain the specialized structures and functions of vestibular hair cells (HCs) in adult mammals. The $2,025,057 grant, awarded to the University of Washington, will employ multi-omics and targeted gene manipulation in mice to...
This federal Project Grant award of $265,410 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA Program 93.173 "Research Related to Deafness and Communication Disorders" aims to investigate the role of mechanotransduction channel components in the development and function of vestibular hair cells. The key objectives are to: 1) Characterize how the heterogeneous regional expression of mechanoelectrical transduction (MET) channel subunits...
This $589,393 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research to elucidate how the neural circuit of the mammalian cochlea assembles during development. The primary objectives are to investigate the roles of inner and outer hair cells, and their innervation by afferent and efferent neurons, in the formation and maturation of the...
This federal Project Grant award of $169,292 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA Program 93.173 "Research Related to Deafness and Communication Disorders" aims to investigate the molecular and functional heterogeneity of vestibular ganglion neurons (VGNs) and their synaptic connections with hair cells in the mouse inner ear. The project, led by researchers at the University of Washington, will employ single-cell RNA sequencing to...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders Federal Grant Program (CFDA 93.173), will provide $301,678 to the University of Florida to conduct research on the biophysical properties and role of biomolecular condensates in the development and maintenance of hair cell stereocilia, which are essential for hearing. The key objectives are to characterize the material...
The National Institute on Deafness and Other Communication Disorders (NIDCD), through its Research Related to Deafness and Communication Disorders program (CFDA 93.173), awarded a $2,119,610 Project Grant to The Johns Hopkins University to study the molecular mechanisms of the clarin-1 and clarin-2 genes and their role in the development and function of mechanosensory hair cells. The project aims to elucidate how defects in these genes contribute to hearing loss. The research will use...
This federal Project Grant award, titled "Cochlear Resident Tissue Macrophages in Normal Cochlear Development and the Response to CMV Infection," is funded by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The $1,890,178 grant was awarded to the University of Utah to investigate the role of fetal tissue macrophages in the development of the cochlea and how...
This Project Grant award of $767,494 from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) supports the development of human induced pluripotent stem cell-derived inner ear organoid platforms for modeling and treating genetic hearing and balance disorders. The key objectives are to: 1) Establish and optimize 3D inner ear organoid systems from patient-derived stem cells, and 2) Test CRISPR/Cas9-based gene...
This $218,750 federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) will support research to characterize the alternative splicing landscape and regulation in the mouse inner ear at single cell resolution. The award to Vanderbilt University Medical Center aims to identify cell type-specific diversity of alternatively spliced mRNA and the role of RNA...
This Project Grant award in the amount of $693,856 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The grant will fund research at the University of California, San Francisco (UCSF) to investigate the structure and function of coordinated neural activity in the auditory system of awake mice. The research will use high-density electrophysiology, optogenetics,...