Project Grant R01CA300571
- Federal Grant Award Summary St. Jude Children's Research Hospital Inc. received a $3,032,826 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), effective September 1, 2025, through August 31, 2030. The FUSONC Program Project delivers collaborative basic and translational research services focused on elucidating the mechanisms by which fusion oncoproteins (FOS)—abnormal proteins arising from gene translocations—drive...
- Federal Grant Award Summary St. Jude Children's Research Hospital Inc. received a $767,328 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) beginning August 1, 2025, and concluding July 31, 2030. The grant supports research investigating pre-messenger RNA (pre-mRNA) splicing vulnerabilities in neuroblastoma, a cancer responsible for 15% of childhood cancer-related deaths. The research focuses on testing the therapeutic efficacy of...
- Federal Project Grant Award Summary St. Jude Children's Research Hospital Inc. received a $768,713 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective August 1, 2025, through July 31, 2030. This award supports fundamental research to advance understanding of epigenetic mechanisms controlling neuroblastoma cell state plasticity and treatment resistance. The project specifically investigates the role of histone...
- Federal Project Grant Award Summary St. Jude Children's Research Hospital Inc. received a $579,874 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) on August 20, 2025, with a completion date of July 31, 2030. This award supports a career development initiative (K08) focused on developing cellular immunotherapy approaches for pediatric patients with relapsed/refractory sarcomas. The project centers on conducting a Phase I clinical trial...
- Federal Project Grant Award Summary St. Jude Children's Research Hospital Inc. received a $290,017 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded on July 15, 2025, with a completion date of June 30, 2030. This grant supports a mentored research training and career development initiative led by Dr. Patel to investigate persistent cell populations in rhabdomyosarcoma (RMS), the most common childhood soft tissue sarcoma....
- Federal Project Grant Award Summary St. Jude Children's Research Hospital Inc. received a $1,049,120 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) awarded on May 21, 2025, with completion scheduled for April 30, 2030. The grant funds fundamental research to dissect neomorphic functions mediated by mutant-specific structures of the Speckle-Type POZ Protein (SPOP), a substrate receptor of the Cullin3-Ring Ubiquitin Ligase (CRL3). The...
- Federal Grant Award Summary Award Details: St. Jude Children's Research Hospital Inc. received a $1.54M Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) effective September 1, 2025, through August 31, 2030. The award supports the Evaluation of Cardiovascular Health Outcomes Among Survivors 2 (ECHOS-2) study, which addresses a critical survivorship care gap in the pediatric cancer population. Products and Services: The grant...
- St. Jude Children's Research Hospital Inc. received a $151,040 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) awarded January 12, 2026, with completion targeted for July 31, 2028. The grant supports research to elucidate the role of an essential transcription factor in SWI/SNF (SWItch/Sucrose Non-Fermentable)-mutant rhabdoid tumors (RTs), a lethal childhood cancer driven by biallelic inactivation of the SMARCB1 tumor suppressor gene. The...
- Federal Project Grant Award Summary St. Jude Children's Research Hospital Inc. received a $508,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 5, 2025, with a completion date of March 31, 2030. The award supports fundamental research investigating epigenetic gene regulation mechanisms that control stem cell fates during embryogenesis, with particular focus on...
- This Project Grant award for $1,340,665.00 was provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) to St. Jude Children's Research Hospital Inc. The award supports research focused on the FGFR pathway as a lead therapeutic vulnerability in pediatric ependymoma, a type of brain cancer in children. The project will be conducted over 3 years, from September 1, 2023 to August 31, 2026, and aims to advance the development of effective...
St. Jude Children's Research Hospital Inc. received a $617,486 Project Grant award from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) effective March 13, 2026, with a completion date of February 28, 2031. The grant funds research investigating the transcriptional suppression of innate immunity by chimeric transcription factors, specifically the PAX3-FOXO1 and PAX7-FOXO1 fusion oncoproteins that drive alveolar rhabdomyosarcoma (ARMS), an aggressive childhood soft tissue sarcoma with poor survival outcomes despite intensive chemotherapy and radiotherapy. The research deliverables include mechanistic investigations into how PAX3/7-FOXO1 suppresses cancer cell-intrinsic immune responses by silencing cytosolic RNA and DNA sensing pathways that normally activate type I interferon responses. The project comprises two specific aims: (1) investigating the mechanism by which dsRNA (double-stranded RNA) sensing is silenced by PAX3/7-FOXO1, and (2) investigating the mechanism by which cytosolic DNA sensing is suppressed by these fusion oncoproteins. Upon completion, the research is expected to generate novel insights into how chimeric transcription factors evade immunosurveillance and provide a scientific foundation for developing innovative immunotherapies targeting fusion-positive ARMS and potentially other PAX3/7-FOXO1-driven cancers.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $617.5k | 3/13/26 |