Project Grant R01CA299257

Award Date 4/3/25
Completion Date 3/31/30
Dollars Obligated $643K
Federal Grant Program
93.396
Assistance Type
Project Grant
Place of Performance
Dallas, TX 75390, USA
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This $984,000 federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Treatment Research program (CFDA 93.395), aims to advance the treatment of immune-resistant cancers. The grant will fund research at the University of Texas Southwestern Medical Center to integrate nanotechnology, STING signaling, dendritic cell biology, and immuno-oncology approaches. Key objectives include designing a pH-sensitive, hypoxia-activated nanoparticle STING agonist to selectively...
This federal Project Grant award, totaling $701,876 and funded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research), will support a research project titled "A Systems-Level Approach to Therapeutically Target STING in Cancer" at Weill Medical College of Cornell University. The project aims to utilize a novel technology called SatSeq to map the structure-function landscape of the immune-related protein STING and its role in cancer progression. Specifically, the...
This Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) provides $935,004 over a 5-year period from July 1, 2024 to June 30, 2029 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The objective is to elucidate the mechanisms by which tumor-infiltrating T cells experience cell death induced by the STING signaling pathway in response to cyclic GMP-AMP (cGAMP) importation, and to develop strategies for...
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This Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) is supporting research at the University of Texas Southwestern Medical Center focused on developing improved STING agonist cancer therapies. The $642,739 award, active from April 2025 through March 2030, aims to: 1) understand novel lipid-dependent activation and regulatory mechanisms of STING, a key innate immune protein vital for cancer defense; 2) use cryo-EM to dissect the molecular mechanism underlying a novel STING-activating polymer, PSC7A; and 3) evaluate the synergistic antitumor effects of PSC7A nanoparticles loaded with STING agonists and specific lipids in animal tumor models. This research seeks to facilitate the design of next-generation STING agonists that can precisely control immune signaling to achieve maximal antitumor immunity with minimal systemic toxicity.

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