Project Grant R01CA292870
- Federal Grant Award Summary Yale University received a $696,189 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective April 7, 2026, through March 31, 2031. The award funds fundamental research investigating the mechanisms of CD8 T cell differentiation in tumor-draining lymph nodes (TDLN) to advance understanding of immunotherapy response in lung adenocarcinoma (LUAD). The research deliverables include mechanistic studies...
- Federal Grant Award Summary Yale University received a $672,371 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective September 1, 2025, through August 31, 2028. The grant funds development of ultra-sensitive mass spectrometry-based immunopeptidomics technology utilizing digital microfluidics to identify tumor-specific antigens (TSAs) for cancer immunotherapy applications. The project addresses current...
- Federal Grant Award Summary Yale University received a $150,104 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) effective January 16, 2026, through August 31, 2028. The award supports research investigating the impact of aberrant 5-methylcytosine (m5c) messenger RNA (mRNA) modification on translation initiation and cancer development. The project will examine how dysregulated methyltransferase expression in cancer cells affects...
- Federal Grant Award Summary Yale University received a $167,771 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded August 1, 2025, with completion targeted for July 31, 2027. The award supports research to elucidate the mechanisms of a novel human-specific immune checkpoint interaction between SIGLEC-7 and VSIG4 proteins. The research will utilize a humanized mouse platform (MISTRG6-A2) to develop in vivo models that investigate how...
- Federal Project Grant Award Summary Yale University received a $192,564 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) effective September 1, 2025, through August 31, 2028. The award supports research focused on developing a novel dual-target PROTAC (Proteolysis Targeting Chimera)-based protein degrader to address therapy resistance in metastatic castration-resistant prostate cancer (MCRPC). The project leverages a newly developed...
- Federal Grant Award Summary The National Cancer Institute awarded Yale University a $478,532 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2027. This research initiative will investigate the biological and clinical significance of spatial immune heterogeneity in non-small cell lung cancer (NSCLC), with particular focus on characterizing how the spatial distribution of tumor-infiltrating lymphocytes (TILs) and tertiary...
- Federal Grant Award Summary Yale University received a $147,486 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) awarded July 1, 2025, with a completion date of June 30, 2028. This research grant funds investigation into the role of glycosylated RNAs (glycoRNAs)—RNA molecules post-transcriptionally modified with sialylated-N glycans—in acute myeloid leukemia (AML). The project delivers scientific research outputs across three primary aims:...
- Federal Grant Award Summary Yale University received a $1.3 million Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) effective July 1, 2025 through June 30, 2029. The award supports the development of GUAR-T as a novel class of universal cellular immunotherapies for ovarian cancer. This research initiative represents a hypothesis-driven translational effort aimed at advancing cancer immunotherapy to address critical...
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $510,431 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2025 through June 30, 2030. This award supports fundamental research investigating the mechanisms of metastatic recurrence and therapeutic resistance in melanoma, with particular emphasis on understanding how aging influences tumor dormancy and the microenvironment. The research examines Wnt signaling...
- Federal Grant Award Summary Yale University received a $1,004,472 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420), awarded on June 15, 2025, with a completion date of June 14, 2029. The project, titled "Mast Cell Therapy for Ovarian Cancer," is being conducted at Yale's Hamden, Connecticut facility. This award supports advanced biomedical research aimed at developing innovative therapeutic interventions for...
Yale University received a $610,637 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) effective April 1, 2026 through March 31, 2031. The award supports the development and preclinical evaluation of a versatile drug delivery platform utilizing bioadhesive and non-adhesive biodegradable nanoparticles engineered for selective locoregional delivery of cytotoxic and immune conditioning agents to advanced melanoma tumors, the tumor microenvironment, and tumor draining lymph nodes. The nanoparticle platform will be further innovated to enable mRNA (messenger ribonucleic acid) incorporation, with modifications designed to improve therapeutic efficacy for melanoma and other cancers. The research deliverables include comprehensive preclinical studies using mouse models of locally advanced and metastatic melanoma to evaluate immunological effects and abscopal responses to treatment. The project will assess the capacity of intratumoral delivery of bioadhesive nanoparticles carrying anti-tumor cytotoxic agents in combination with non-adhesive nanoparticles delivering immunomodulatory agents to limit tumor growth and facilitate anti-melanoma immunity. The research aims to demonstrate that this multi-armed locoregional delivery strategy will synergize with systemic immune checkpoint inhibitors, with testing of specific drug combinations including exatecan, RG108, and MPLA (monophosphoryl lipid A) in established melanoma models.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $610.6k | 3/31/26 |