This $620,521.00 federal Project Grant award from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) supports research conducted by H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Tampa, Florida.
The research aims to develop an integrated mathematical modeling approach to understand how the aging bone ecosystem drives the evolution and treatment response of multiple myeloma, an incurable bone-destroying cancer. This includes using spatial transcriptomic analysis, in vitro and in vivo data, and optimization algorithms to generate a hybrid cellular automata model that can simulate the effects of standard therapies and inform the development of improved adaptive treatment regimens. The goal is to delay the emergence of resistant disease, particularly in older patients. The funding period spans from January 1, 2025 to December 31, 2029.
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