The National Cancer Institute (NCI) has awarded a $543,221 Project Grant (CFDA 93.396 - Cancer Biology Research) to Albert Einstein College of Medicine in the Bronx, New York to conduct research on targeting lineage plasticity to inhibit basal-like breast cancer progression. The 5-year project aims to define the key dedifferentiated cells required for basal-like breast cancer progression and explore strategies to target these cells for cancer interception. Additionally, the project will elucidate the molecular mechanisms driving dedifferentiation to multipotency in basal-like breast cancer. This research seeks to develop preventive strategies to intercept the malignant progression of this aggressive breast cancer subtype, which disproportionately affects younger women and those of African ancestry. The project commenced on January 1, 2025 and is scheduled for completion on December 31, 2029.
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