The University of Illinois, through a $479,591 Project Grant awarded by the National Cancer Institute's Cancer Biology Research program (CFDA 93.396), is conducting a 5-year research project to elucidate the mechanisms by which metastatic breast cancer cells induce permeability of the blood-brain barrier (BBB) to facilitate brain metastasis. The key objectives are to: 1) determine how cancer-derived glycosylated Fetuin-A protein opens the BBB, and 2) examine how cancer-derived Fetuin-A facilitates breast cancer brain metastasis in animal models. The research aims to reveal essential insights into the process of breast cancer brain metastasis and develop a novel strategy to prevent it by inhibiting Fetuin-A-induced BBB permeability. Findings from this comprehensive, 5-year project could significantly advance understanding of the biological mechanisms underlying brain metastasis and contribute to new therapeutic approaches.
Generated 3/18/25, 3:58 AM