This Project Grant award from the National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), supports the development of a novel theranostic prostate cancer-specific CAR-T cell approach. The key objectives are to: 1) Evaluate the therapeutic efficacy of DLL3-specific CAR-T cells in neuroendocrine prostate cancer (NEPC) models; 2) Develop DLL3/PSMA bi-specific CAR-T cells and assess their ability to target tumors with heterogeneous antigen expression; and 3) Validate the use of clinically approved imaging tracers to track the CAR-T cells and monitor tumor response. The $720,416 award, effective September 4, 2024 through August 31, 2029, will be conducted by the Sloan-Kettering Institute for Cancer Research, a prominent non-profit cancer research organization. The research aims to advance CAR-T cell-based immunotherapies for metastatic NEPC, a challenging prostate cancer subtype, by leveraging the institute's expertise in CAR-T cell design, molecular imaging, and translational research.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $720.4k | 9/4/24 |