This $450,997 Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) supports research at Rutgers, The State University of New Jersey, to investigate the role of the urea cycle enzymes (UCEs) in the development of hepatocellular carcinoma (HCC), the most common form of liver cancer. The project aims to determine how the suppression of UCE expression contributes to HCC tumor growth driven by oncogenic β-catenin, study the mechanisms by which β-catenin regulates UCE transcription, and evaluate whether lowering the body's ammonia burden can be a therapeutic strategy for treating or preventing HCC. The five-year project will leverage mouse models and molecular biology techniques to enhance understanding of HCC biology and explore potential new approaches for managing this form of cancer.
Generated 1/28/25, 7:08 AM