This $517,618 Project Grant awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports fundamental research at the University of Pittsburgh on the role of the TREM1 immune receptor in the tumor microenvironment of leukemia. The key objectives are to examine how TREM1 expression in leukemia-associated macrophages (LAMs) promotes leukemia development and progression, and to investigate the functional interplay between TREM1+ LAMs and leukemia stem cells. This multi-year research program leverages mouse models and patient-derived xenograft studies to gain mechanistic insights into how TREM1 signaling in LAMs influences the growth and migration of leukemic cells. Findings from this grant-funded project are expected to provide critical new understanding of the immunological drivers of leukemogenesis, potentially leading to new therapeutic approaches targeting the tumor microenvironment.
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