The National Cancer Institute (NCI) awarded a Project Grant (CFDA 93.396 - Cancer Biology Research) totaling $721,723 to the Beckman Research Institute of the City of Hope in Irwindale, CA. The grant supports research to study the transition from chronic lymphocytic leukemia (CLL) to the more aggressive Richter's transformation (RT), a deadly complication. The research aims to determine the key cellular pathways and immune environment factors driving the CLL-to-RT transition, with the goal of identifying vulnerabilities and developing novel combinatorial targeted and immune therapy approaches to overcome RT. The project leverages a newly established murine model of RT developed by the Wang Laboratory, as well as ongoing clinical trials of CDK9 inhibitors and immunotherapies for RT and lymphoma led by the Danilov Laboratory. The research is expected to be completed by November 30, 2029.
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