This $711,161 Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research to define and validate guidelines for interpreting commonly used patient-reported outcome measures (PROMs) for pain and physical function in patients with advanced knee osteoarthritis. The research will leverage existing data from the Osteoarthritis Initiative and a 12-site total knee replacement cohort to develop guidelines tailored to patients' comorbidities and demographics. A prospective validation study and evaluation of PROM interpretation guideline adoption by clinicians are also planned. This research aims to support consistent PROM interpretation and inform future knee osteoarthritis clinical care and research. A sub-award of $68,775 was made to the University of Massachusetts Lowell to contribute to this project.