The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) has awarded a $608,358 project grant (R01AR083130) to the Trustees of Indiana University, doing business as Indiana University Indianapolis (IU Indianapolis), to study the role of the neuropeptide calcitonin gene-related peptide (CGRP) in bone healing and chronic pain following bone fractures in a murine model. The research aims to identify new non-opioid analgesics that do not compromise bone healing. This project, funded under the NIAMS Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will run from July 2024 to May 2029. The research conducted at IU Indianapolis may provide new insights into how modulating CGRP can regulate bone healing, inflammation, and pain, potentially leading to improved fracture healing and reduced reliance on opioid pain management.
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