Project Grant R01AI192847

Award Date 8/1/25
Completion Date 7/31/30
Dollars Obligated $660K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
California, USA
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This Project Grant award of $666,567 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of California, Los Angeles (UCLA) to investigate the transcriptional regulation of human natural killer (NK) cell function in response to viral infections, such as human cytomegalovirus (HCMV). The key objectives are to determine the mechanisms by which the transcription factor MEF2C regulates NK cell...
This federal Project Grant award of $643,718 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how interferon-regulatory factors (IRFs) and STAT transcription factors remodel the epigenome and chromosome organization of macrophages to reprogram their immune responses. The research aims to: 1) dissect the roles of innate immune IRFs in de novo enhancer formation, 2)...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $156,080 to the University of Utah to conduct research on how natural killer (NK) cells function and recognize different peptides. The goal is to determine how the inhibitory receptor LY49C allows NK cells to display differential effector functions when presented with different peptides, without direct contacts...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $147,486.00 to the Icahn School of Medicine at Mount Sinai to conduct high-resolution immunological characterizations of a novel murine model of chronic hepacivirus infection. The goal is to study the evolution of immune dysfunction over the course of infection and better understand the molecular drivers of T cell exhaustion and viral...
This $510,306 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to advance the understanding of virus-host interactions for developing a cure against chronic hepatitis B virus (HBV) infections. The primary goal is to investigate the mechanisms by which interferon-alpha treatment can lead to a functional cure for HBV, as well as explore the impact of HBV...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) is supporting research to investigate the role of chromatin-associated RNA processing in early B-cell development. The primary focus is on understanding the mechanisms by which the RNA exosome and RNA helicases act during VDJ recombination, a critical process for generating antibody diversity. The $147,486 award will fund the use of novel mouse models...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $153,512.00 to Emory University to investigate the role of intrahepatic (liver-resident) plasma cells in clearing hepatitis C virus (HCV) infection. The goal is to characterize the mechanistic origins of these plasma cells and determine if they are primed locally within the liver or follow traditional homing...
This Project Grant award of $582,618.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The grant supports research to determine the mechanisms by which RNA N6-methyladenosine (m6A) and pseudouridine (Ψ) modifications modulate SARS-CoV-2 replication, gene expression, immunity, and pathogenesis. Key activities include using CRISPR-Cas9 to knock out host RNA...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate the mechanisms underlying hepatitis delta virus (HDV) pathogenesis. The $249,000 award to the University of Southern California aims to: 1) Determine the proviral role of the MDA5 signaling pathway in HDV infection, and 2) Define the mechanism of HDV-induced hepatocyte programmed cell death. The...
This $423,500.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at the University of Utah to investigate the role of invariant natural killer T (iNKT) cells in shaping the immune response to Plasmodium infection, which can lead to the severe neurological condition of cerebral malaria. The research aims to define how the T cell receptor (TCR) signaling properties of different iNKT cell...

This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $659,663 to the Beckman Research Institute of the City of Hope to investigate the role of RNA modification in the development and function of invariant natural killer T (iNKT) cells and their impact on liver disease.

The key objectives are to: 1) Elucidate how the RNA modification regulator YTHDF2 controls iNKT cell development, and 2) Determine how YTHDF2-deficient iNKT cells exacerbate liver injury through the CSF1-macrophage-TNF-α axis. This research aims to advance the understanding of how RNA modifications influence innate immune cells and their role in autoimmune hepatitis. The award period runs from August 1, 2025 to July 31, 2030.

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