Project Grant R01AI192672
- This $633,218 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research CFDA Program (93.855), supports research to characterize the mechanism of inhibition of the cholesterol transporter protein Pfncr1 in the malaria parasite. The research aims to use structural, physiological, genetic, and cell biological approaches to investigate two new inhibitors of Pfncr1 that are predicted to bind away from the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $223,176 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to the University of Pennsylvania to support research on the molecular architecture of the Cryptosporidium host-parasite interface. This research aims to better understand the intricate ultrastructural features and function of the interface between the Cryptosporidium parasite and its host cells, as...
- This Project Grant award of $812,603 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Houston System aims to refine a new class of calcium dependent protein kinase 1 (CDPK1) inhibitors and define optimal tissue targeting for the treatment of cryptosporidiosis, a significant public health threat with limited treatment options. The researchers will conduct structure-activity relationship analysis and...
- This $616,588 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to understand the molecular function of unstudied genes in the fungal pathogen Cryptococcus neoformans, a leading cause of fungal meningitis. The research team at the University of California, San Francisco constructed and phenotypically profiled a comprehensive gene deletion collection for C. neoformans to elucidate the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $230,808 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in St. Louis, Missouri. The funding will support research to identify heme-binding proteins in the malaria parasite Plasmodium falciparum and investigate their role in maintaining heme homeostasis. The project aims to better understand how the parasite detoxifies heme, an essential but redox-active...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $109,076 project grant to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The grant supports research on T cell trafficking to the small intestine during Cryptosporidium infection. The research aims to investigate the effect of Cryptosporidium infection on...
- This $300,000 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development of novel vaccine candidates for cryptosporidiosis, a leading cause of diarrhea and malnutrition in children in low- and middle-income countries. The grantee, Immport Therapeutics Inc. (doing business as Antigen Discovery Inc.), will formulate cryptosporidium proteins and a mucosal...
- This federal Project Grant award of $158,433 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Clemson University. The grant supports research to identify the metabolic mechanisms that allow the pathogenic fungus Cryptococcus neoformans to tolerate high levels of carbon dioxide, which is a key virulence trait enabling this fungus to cause severe and often fatal infections in humans. The...
- This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
- This Project Grant award, valued at $232,073 and awarded on November 12, 2024, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The research project aims to explore the impact of Cryptococcus neoformans (CN) replicative aging on infection in AIDS patients, particularly the host-pathogen dynamics in microglia co-infected with CN and HIV-1. The project will investigate the...
This $715,894 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) supports research to elucidate the role of microbial metabolites in influencing mitosome function in the enteric pathogen Cryptosporidium. The primary objectives are to characterize the function of an ADP/ATP carrier in generating the mitosome's membrane potential, determine the role of a putative pyridoxal phosphate transporter, and explore the iron-sulfur cluster biosynthesis pathway. This research aims to improve understanding of Cryptosporidium mitochondrial biology and identify potential therapeutic targets, as the existing FDA-approved drug nitazoxanide has limited effectiveness against this disease, which causes severe, chronic diarrhea in immunocompromised patients and infants. The award period is from August 8, 2025 to July 31, 2030, with the research to be conducted at The Washington University.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $715.9k | 8/7/25 |