Project Grant R01AI186609

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,421,737 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to the University of North Carolina at Chapel Hill (UNC-CH) to study the role of histone decrotonylation in regulating HIV latency. The project aims to determine the molecular mechanisms by which histone decrotonylation, distinct from histone deacetylation, plays a critical part in the establishment of HIV latency. The research will explore how pharmacologically modulating decrotonylation can prevent HIV from entering a latent state. UNC-CH, a major public research university, will conduct this 5-year research effort with the goal of developing better strategies to address the persistent HIV reservoirs in people living with HIV. The university has extensive experience managing large-scale federal biomedical research grants and contracts.