Project Grant R01AI181890
- This federal Project Grant award for $197,588.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to investigate the drivers of beneficial effects of influenza A virus co-infection. The principal investigator at Emory University will use the Influenza A/Netherlands/602/2009 (H1N1) virus to generate viral variants and evaluate the density-dependence of discrete...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $230,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Scripps Research Institute to develop a broad-spectrum influenza vaccine. The project aims to evaluate recently discovered neuraminidase broadly neutralizing antibodies (NA BNAbs) and engineer NA immunogens that can engage diverse BNAb precursors, a strategy called germline targeting. This protein engineering effort...
- This $3,085,097 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research CFDA program, supports research to characterize a newly discovered class of inhibitory viral proteins encoded by deletion-containing viral genomes (DELVGs) in influenza virus infections. The research aims to 1) define the interference activity and mechanism of action of these DELVG-encoded proteins (DPRs), 2) determine the full...
- This $108,486 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports the development of soluble and membrane-bound immunogens to shepherd HIV-1 MPER-specific B-cell receptor (BCR) maturation. The goal is to create immunogens that can elicit broadly protective antibodies against influenza by targeting the conserved anchor epitope in the hemagglutinin stem region. The awardee,...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,323,410 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Georgia State University Research Foundation Inc. The grant supports advancing the development of prodrug conjugates of 4'-fluorouridine (4'-FLU), a pyrimidine analog with broad oral efficacy against influenza viruses, and at least one non-nucleoside inhibitor of the influenza virus polymerase complex. The overarching...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides funding of $3,078,308 over a 4-year period from August 1, 2025 to July 31, 2029. The research project aims to determine the TCR-dependent and epigenetic mechanisms that drive secondary CD4+ T cell responses to influenza infection. Key objectives include understanding how prior antigen exposure, either via...
- This Cooperative Agreement award of $1,352,292 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports a research project to develop a high-resolution profiling and computational modeling framework for studying influenza virus-immune dynamics during natural infection. The project aims to address critical knowledge gaps in understanding the human immune response to influenza viruses, with the goal...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $147,486 Project Grant to The New York Structural Biology Center, Inc. on January 14, 2025. The grant supports research to define the structural diversity and functional implications of internal ribosome entry site (IRES) elements found in RNA viruses, which enable viral infection by facilitating translation initiation on viral genomes. The...
- This Project Grant award of $489,965.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The award supports research focused on understanding the role of IFN/SOCS1 signaling during post-influenza bacterial infections, particularly Streptococcus pneumoniae. Key objectives include elucidating the mechanisms by which SOCS1 exacerbates antibacterial complications after influenza...
- The Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) provides $299,968 to Viva Viral Vaccines, Inc. to develop a broad-spectrum, multivalent vaccine platform to protect against seasonal and pandemic influenza strains. The platform leverages innovations to rapidly produce and deploy highly protective vaccines that target the conserved influenza neuraminidase (NA)...
This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to define the structure-function relationships that regulate the influenza virus proteins NS1 and NEP. The $587,885 award, with a project period from September 2025 to August 2030, will support research at the University of Alabama at Birmingham (UAB) to investigate the mechanistic and structural underpinnings of how these viral proteins govern the influenza lifecycle. By filling critical gaps in the understanding of influenza biology, this research could identify novel targets for the development of antiviral therapeutics against influenza, a serious public health concern.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $587.9k | 9/18/25 |