The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,283,291 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The grant, titled "KSHV-Mediated Metabolic Reprogramming for LANA Expression and Viral Persistency," aims to study how the Kaposi's sarcoma-associated herpesvirus (KSHV) alters host cell metabolism to promote viral persistence and oncogenesis. The research will explore the virus-induced changes in spermidine and proline biosynthesis within a 3D cell culture system, which better mimics in vivo conditions compared to 2D systems. The findings are expected to contribute to the broader understanding of metabolic reprogramming in cancer. The project period runs from June 14, 2024 to April 30, 2029.
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