Project Grant R01AG098927
Award Date 1/1/26
Completion Date 12/31/30
Dollars Obligated $657K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Rochester, NY 14642, USA
Similar Awards
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,221,450.00 to the University of California, Irvine to investigate the role of the retrosplenial cortex (RSC) in the progression of Alzheimer's disease (AD) pathogenesis in mice and humans. The key objectives are to: Define how neuronal hyperexcitability in the RSC contributes to the development of AD-related behavioral deficits in mice, and the underlying molecular mechanisms. Determine the...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $162,486 project grant to The Research Foundation For The State University Of New York (operating as Upstate Medical Center) on January 24, 2025. The project aims to enhance understanding of the biological signatures that distinguish subgroups of Alzheimer's disease (AD) patients using state-of-the-art computational approaches to jointly analyze genetic, epigenetic, and neuroimaging...
- The federal Project Grant award for "MULTISCALE MODELING AND EMPIRICAL STUDIES OF NORMAL AND PATHOLOGICAL BRAIN AGING" was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866). The $636,342 award will support research at Boston University Medical Campus from August 1, 2025 to April 30, 2030. The project aims to investigate the relationship between myelin dystrophy, synapse loss, and neuronal hyperexcitability in the aging brain, and how these...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,851,569.00 in funding to The Washington University to conduct research on how early brain development informs later neurodegeneration, with a focus on Alzheimer's disease. The project aims to determine if regions of the brain with high plasticity during early development are more susceptible to pathological changes later in life, and if adverse developmental conditions have...
- The Project Grant award titled "ENHANCER-AAVS TO MONITOR AND RESTORE CELL-TYPE SELECTIVE INHIBITORY DEFICITS AND CIRCUIT DYSFUNCTION IN HUMANIZED ALZHEIMER'S DISEASE MODELS" was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The $1,459,072.00 award, granted to the J. David Gladstone Institutes, aims to monitor and manipulate inhibitory interneuron cell populations in mouse models to assess their contribution to...
- This federal Project Grant award of $716,579, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to investigate the role of microglia, the immune cells of the brain, in the progression of Alzheimer's disease (AD). Specifically, the research aims to genetically dissect the relationships between different activated states of microglia and their involvement in complement-mediated synapse loss, which is a key neurobiological driver of cognitive decline in...
- This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- This federal Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), will support research to elucidate the full repertoire of neuropeptidome signatures and their biosynthetic proteases in normal human brain regions, as well as assess dysregulation of neuropeptidomes and biosynthetic proteases in Alzheimer's disease (AD) and mild cognitive impairment (MCI) brain regions compared to age-matched controls. The $3,138,871 award to the...
- This $426,674 federal grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports research to investigate the implications of long-range mossy cell signaling and connectivity in Alzheimer's disease (AD). The project aims to identify ways to remediate the cognitive and emotional impairments associated with AD, with a focus on understanding the role of the dentate gyrus (DG) region of the hippocampus and the activity of glutamatergic mossy...