Project Grant R01AG095017
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,489,452.00 to the University of California, Irvine to investigate circuit vulnerability in the lateral and medial entorhinal cortices in Alzheimer's disease (AD) tauopathy models. The research aims to identify specific neuron subtypes in the entorhinal cortex that are vulnerable to the tau protein pathology in AD, and how this relates to impaired memory function. The project is...
- This federal Project Grant award of $3,221,450.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to define how neuronal hyperexcitability in the retrosplenial cortex (RSC) contributes to the development of Alzheimer's disease (AD)-related behavioral deficits in mouse models. The research aims to determine the effect of inhibiting RSC layer 5 cells on spatial memory and navigation, as well as when hyperexcitability emerges in these cells across different AD...
- The National Institute on Aging (NIA) awarded a $773,816 project grant under the Aging Research federal grant program (CFDA 93.866) to the University of California, Irvine (UCI) to conduct comparative studies on new tau-directed Alzheimer's disease (AD) and AD-related dementias (ADRD) mouse models and human AD/ADRD brain tissues. The project aims to generate single-cell spatial proteo-transcriptomics maps to molecularly characterize aberrant RNA splicing and abnormal protein products in specific...
- This $3,109,079 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of California, Riverside to investigate the role of traumatic brain injury (TBI) across the lifespan in the development of Alzheimer's disease and related dementias (ADRD). The project will use a closed head injury (CHI) TBI mouse model to examine how ADRD risk factors, such as the APOE4 gene and amyloid-beta, interact with TBI at different life stages...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
- This $603,031 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Northwestern University supports a 1-year research study on the clinical, cellular, and pathological features of comorbid Alzheimer's disease and TDP-43 proteinopathies in elderly patients with amnestic dementia. The key objectives are to: 1) identify the shared versus distinct clinical, neuropsychological, and psychiatric characteristics of this condition; 2) determine the cellular...
- This Project Grant award of $353,391.00, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to validate the use of a "Personal Learning Curve" paradigm as a sensitive marker of early memory decline related to Alzheimer's disease (AD) biomarkers in a large, diverse sample of older adults. The study seeks to determine if this digital cognitive assessment tool, which measures learning over repeated evaluations, can detect subtle AD-related memory failures...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $147,656.00 to Emory University to develop the first human locus coeruleus (LC) organoid model to study the role of the LC in the earliest stages of Alzheimer's disease (AD). The goal is to use this novel human cell culture model to understand how the early accumulation of hyperphosphorylated tau in the LC affects neuronal function and norepinephrine transmission, which are linked to the prodromal...
- The National Institute on Aging (NIA) awarded a $3,281,385 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of California, San Diego (UCSD) to leverage 30 years of Alzheimer's disease clinical trials data. The goal is to examine the role of specific patient phenotypes, such as sex/gender, APOE4 status, and polygenic hazard scores, on response to drug or lifestyle interventions. The project will analyze data from 14,602 participants across multiple...
- This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $3,128,129 to the University of California, Irvine to create a Discovery and Trial Ready Cohort for Limbic Predominant Age Related TDP-43 Encephalopathy (TRC LATE). The project aims to validate clinical, neuropsychological, and imaging markers for Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE), identify novel biomarkers and develop risk scores, and conduct trial planning and recruitment science studies. The researchers will recruit and characterize 420 participants aged 85 and older across 5 Alzheimer's Disease Research Centers, with approximately 200 participants enrolled in the trial-ready cohort for future early phase LATE trials.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $491.4k | 8/21/25 | ||
| Not listed | $2.6m | 8/18/25 |