This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $392,709 to the University of California, Los Angeles (UCLA) to analyze the impact of natural aging and HIV-induced accelerated aging on humoral immunity, particularly in the gastrointestinal tract. The study aims to quantify B-cell immune aging in the gut-associated lymphoid tissue (GALT) and peripheral blood of people living with HIV and people without HIV, ranging in age from 18 to 60-65...
This National Institute on Aging (CFDA 93.866 Aging Research) Project Grant award of $619,511 will fund a study at the University of Miami to investigate the impact of aging on metabolic deficits and immune dysfunction in people living with HIV (PWH). The 5-year study (July 2024 - June 2029) will evaluate the serum metabolic profiles of PWH and how this influences the function, phenotype, and transcriptional profiles of key immune cell types. The research aims to identify senescent and metabolic...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $211,950 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of California, Irvine to investigate the role of nucleic acid-containing immune complexes in driving immune activation and endothelial dysfunction in people living with HIV who are on antiretroviral therapy. The key research objectives are to: 1) Measure the inflammatory response to these nucleic acid-containing immune...
This federal Project Grant award, valued at $383,750.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The primary objective of the grant is to study the molecular, neuro-immune, and behavioral changes that occur during HIV-associated progressive aging using a long-term humanized mouse model. Key research activities include: Evaluating the impact of HIV latency and antiretroviral therapy (ART) on premature aging and functional...
This $197,366 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to advance the scientific understanding of how the human immune system naturally restricts a specific subset of HIV, known as X4-tropic virus. The grant recipient, The Washington University, will conduct research to: 1) characterize the molecular mechanisms driving the immune system's restriction of...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $854,360.00 to support research on understanding the role of HIV RNA modifications in chronic inflammation for people living with HIV on antiretroviral therapy. The research aims to identify the molecular mechanisms linking HIV RNA modifications to innate immune activation in HIV-infected macrophages, as well...
This federal Project Grant award, totaling $794,045.00, was issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to study the host cellular drivers of class II cytokine-mediated viral control across different stages of HIV infection, from acute infection to antiretroviral therapy (ART) interruption. The key products and services to be delivered under this grant include: 1) implementing...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $616,200.00 to Georgetown University to conduct research on the pro-inflammatory functions of granzymes and their impact on endothelial inflammation and injury in people living with HIV (PWH). The key objectives are to: 1) Examine the regulation of granzyme expression by memory CD8 T cell subsets and...
This $775,391 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research on modulating the immunoregulatory protein galectin-9 to target HIV persistence. The principal grantee, Vitalant Research Institute, will collaborate with researchers at Weill Cornell Medicine and Yale University to elucidate the mechanisms by which galectin-9 influences the HIV reservoir and viral rebound, with the goal...
The National Institute on Aging (NIA), through its Aging Research program (CFDA 93.866), has awarded a $534,644.00 Project Grant to Temple University - Of The Commonwealth System Of Higher Education. The grant aims to characterize how the HIV-1 virus decreases neuronal clearance, leading to the progression of HIV-associated neurocognitive disorders like motor dysfunction. Key research activities include determining the post-translational regulation of the SNAPIN protein and its impact on...