This $149,880 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to The Johns Hopkins University will support research into the effects of aging on spatial orientation and balance. The project aims to (1) parse out how sensory integration for spatial orientation changes with aging, and (2) examine whether age-related vestibular physiologic changes, as measured by a video-oculography technique, correspond to spatial orientation errors and fall risk in...
This $274,440 federal Project Grant award was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The project aims to investigate the interplay between age-related auditory and vestibular deficits and their effects on gait and spatial navigation. The research will employ comprehensive assessments of auditory and vestibular function, gait analysis, and spatial...
This $804,795 Project Grant was awarded on September 18, 2024 by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding supports a comprehensive research project investigating the neural mechanisms underlying the relationship between gait and cognitive function in individuals with subjective cognitive decline and a family history of Alzheimer's disease. The project aims to determine how declines in vestibular system function and...
The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) received a $435,582 Project Grant award from the National Institute on Aging (NIA) under the Aging Research grant program (CFDA 93.866) to study the mechanisms of head and neck control during falls in balance-impaired older adults. The project aims to determine how vestibular function and neck muscle mechanics contribute to head control during laboratory-induced falls and head perturbations. The research team, which...
This federal Project Grant award of $620,240 from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) supports an observational study examining vestibular pathophysiology and clinical outcomes in patients with sporadic vestibular schwannomas (SVS) and neurofibromatosis type 2-related schwannomatosis (NF2/VS). The primary objectives are to: Measure vestibular dysfunction, relate it to clinical disability,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $676,731 to Arizona State University to identify specific aspects of balance and reactive stepping that are related to falls in people with Parkinson's disease (PD). The goals of this 5-year project are to: Assess the relationship between reactive balance, standing balance, and prospectively measured falls in 100 individuals with PD at risk for falls. This will identify the critical balance...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $407,479 to Senaptec Inc. to develop an in-home sensory training therapy using specialized eyewear ("strobes") to mitigate falls risk among older adults. The project aims to modify the existing strobe design to accommodate prescription lenses and improve functionality in low-light home settings, and to conduct clinical efficacy studies to enable FDA clearance. The goal is to bring this...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $589,483 to Wayne State University to assess in vivo changes in central neuronal activation, molecular indicators of synaptic transmission, and motor function in response to vestibular nerve hypofunction generated by noise exposure. The project aims to evaluate the contributions of...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $242,310 to the University of Illinois to investigate differences in reactive balance control and motor adaptation between older adults with mild cognitive impairment (MCI) and cognitively intact older adults. The study aims to mechanistically understand how MCI pathology contributes to balance impairment and increased fall risk in this population. It will examine biomechanical,...
This $828,022 federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) supports research to identify and characterize nonlinear response properties and effects of aging on cervical and ocular vestibular evoked myogenic potentials (VEMPs) in humans. The overall goal is to create an early-detection model of vestibular degradation and develop profiles of vestibular aging, which...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $632,334 to the Massachusetts Eye and Ear Infirmary to investigate the contributions of vestibular, somatosensory, and visual dysfunction to imbalance and falls in older adults. The research aims to determine how sensory deficits and central processing changes impact standing balance, with a focus on vestibular function. The award will fund a large cohort study using quantitative measures of posture, gait, and falls, as well as computational modeling to understand central sensory integration. The study will also develop a template for imbalance due to vestibular damage. Sub-awards to Westmont College, Hebrew Rehabilitation Center, and Brigham & Women's Hospital will provide expertise in closed-loop balance modeling, assessment of balance in vulnerable older adults, and statistical analysis, respectively. This research is intended to advance understanding of the neural mechanisms underlying balance and fall risk in aging, towards the long-term goal of developing targeted interventions to mitigate fall hazards.