Project Grant R01AA031680
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) program, supports a $559,180 research project to investigate neurobiological factors underlying Alcohol Use Disorder (AUD) with and without comorbid cigarette smoking. The project aims to identify AUD-associated differences in DNA methylation and RNA expression in the nucleus accumbens and dorsolateral prefrontal cortex, key brain regions...
- This $407,812 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 Alcohol Research Programs) will fund a study by the University of Oregon examining the dynamic associations between impulsivity, craving, and co-use of alcohol, cannabis, and nicotine among young adults. The study aims to collect intensive longitudinal data from 250 young adults to investigate how impulsiveness and craving vary between and within different substance use episodes, with a...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $2,365,880 to the University of Tennessee Health Science Center to fund a research project titled "Dissecting the Neurobiological Basis of Social Control over Alcohol Self-Administration." The project aims to develop a preclinical model to investigate how social context and alcohol dependence interact to influence alcohol...
- This federal Project Grant award for $156,486.00 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The goal of the project is to investigate the role of beta2 nicotinic acetylcholine receptors in the insula-BNST pathway and their impact on ethanol consumption and abstinence-induced negative affect. The awardee, Wake Forest University Health Sciences, will conduct research to better understand the molecular mechanisms...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a 5-year, $597,000 Project Grant titled "Sex-Dependent Shifts in Behavioral Profiles and Cortical Signaling Following Adolescent Binge Drinking" to The Pennsylvania State University. The grant, funded under CFDA 93.273 Alcohol Research Programs, aims to characterize changes in behavior, cortical adaptations in somatostatin neuron function and peptide signaling, and functional connectivity following adolescent...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA, CFDA 93.273 Alcohol Research Programs) provides $647,330 to Wake Forest University Health Sciences to conduct research on the role of epigenetics in predisposing the brain to risky alcohol use. The researchers will perform a longitudinal genome-wide DNA methylation analysis of the rhesus macaque dorsolateral prefrontal cortex to identify biomarkers associated with future alcohol drinking levels. The goal...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $105,132 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kentucky Research Foundation. The grant, titled "Uncovering the Functional and Mechanistic Dysregulation of Monocytes After Abstinence and Post-Abstinence Drinking," will leverage a rhesus macaque model to investigate the persistent functional, transcriptional, and epigenetic changes in peripheral monocytes induced by...
- This $232,316 Project Grant awarded by the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) supports research to investigate the role of a novel dynorphinergic circuit in the central amygdala and its connection to the nucleus accumbens. The research aims to understand how this circuit is modulated by chronic pain and fentanyl abstinence, and how it contributes to binge-like alcohol drinking behavior, pain-related cognitive effects, and reinstatement of...
- This federal Project Grant award of $396,643 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) supports research to elucidate the mechanisms underlying stress-potentiated ethanol drinking. The project aims to investigate the role of the histone methyltransferase G9a and its effects on dynorphin-positive neurons in the nucleus accumbens to regulate this behavior. Key objectives include testing the hypothesis that G9a's effects on...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $248,999 to Virginia Commonwealth University to explore the genetic and neurocognitive mechanisms underlying the co-occurrence of alcohol use/problems and suicidal thoughts and behaviors. The overarching goal is to examine how aggregate genetic liability and decision-making processes may contribute to this co-occurrence. The 3-year project period runs from...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $585,203 to Pennsylvania State University to conduct research on the interactions between TLR3 and the cholinergic system, and how they underlie the co-use of alcohol and nicotine through effects on neuroimmune signaling. The 5-year project will utilize a custom-designed system to allow rats to self-administer both nicotine vapor and liquid alcohol, in order to investigate the individual and sex differences in self-administration patterns and their correlation with changes in neuroimmune markers in the brain. The research aims to improve understanding of the mechanisms behind the increased negative health outcomes associated with combined alcohol and nicotine use, including higher rates of certain cancers.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/19/25 | ||
| Not listed | $585.2k | 9/12/25 |